S
Santhosh Sethuramanujam
Researcher at University of Victoria
Publications - 18
Citations - 387
Santhosh Sethuramanujam is an academic researcher from University of Victoria. The author has contributed to research in topics: Retina & Excitatory postsynaptic potential. The author has an hindex of 8, co-authored 18 publications receiving 294 citations. Previous affiliations of Santhosh Sethuramanujam include University at Buffalo.
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Journal ArticleDOI
Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate
Fuguo Wu,Fuguo Wu,Tadeusz J. Kaczynski,Santhosh Sethuramanujam,Renzhong Li,Renzhong Li,Varsha Jain,Malcolm M. Slaughter,Malcolm M. Slaughter,Xiuqian Mu +9 more
TL;DR: It is reported that ectopic expression of Pou4f2 and Isl1 in the Atoh7-null retina using a binary knockin-transgenic system is sufficient for the specification of the RGC fate.
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A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina
Santhosh Sethuramanujam,Amanda J. McLaughlin,Geoffery deRosenroll,Alex Hoggarth,David J. Schwab,Gautam B. Awatramani +5 more
TL;DR: It is found that ACh initiates responses to motion in natural scenes or under low-contrast conditions, and mixed transmission plays a central role in shaping directional responses of DSGCs.
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Specific Wiring of Distinct Amacrine Cells in the Directionally Selective Retinal Circuit Permits Independent Coding of Direction and Size
Alex Hoggarth,Amanda J. McLaughlin,Kara Ronellenfitch,Stuart Trenholm,Rishi Vasandani,Santhosh Sethuramanujam,David J. Schwab,Kevin L. Briggman,Gautam B. Awatramani +8 more
TL;DR: It is demonstrated that increasing ambient illumination leads to the recruitment of GABAergic wide-field amacrine cells (WACs) endowing the DS circuit with an additional feature: size selectivity, which permits high-fidelity direction coding over a range of ambient light levels, over which sizeSelectivity is adjusted.
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The Antipsychotic Drug Loxapine Is an Opener of the Sodium-Activated Potassium Channel Slack (Slo2.2)
Bruno Biton,Santhosh Sethuramanujam,Kelly E. Picchione,Arin Bhattacharjee,Nejla Khessibi,Francoise Chesney,Christophe Lanneau,Olivier Curet,Patrick Avenet +8 more
TL;DR: In dorsal root ganglion neurons, loxapine was found to behave as an opener of native KNa channels and to increase the rheobase of action potential.
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Retinal direction selectivity in the absence of asymmetric starburst amacrine cell responses.
TL;DR: It is demonstrated that direction selectivity in downstream ganglion cells remains remarkably unaffected when starburst dendrites are rendered non-directional, using a novel strategy combining a conditional GABAA α2 receptor knockout mouse with optogenetics.