A Central Role for Mixed Acetylcholine/GABA Transmission in Direction Coding in the Retina
Santhosh Sethuramanujam,Amanda J. McLaughlin,Geoffery deRosenroll,Alex Hoggarth,David J. Schwab,Gautam B. Awatramani +5 more
TLDR
It is found that ACh initiates responses to motion in natural scenes or under low-contrast conditions, and mixed transmission plays a central role in shaping directional responses of DSGCs.About:
This article is published in Neuron.The article was published on 2016-06-15 and is currently open access. It has received 71 citations till now. The article focuses on the topics: gamma-Aminobutyric acid & Glutamatergic.read more
Citations
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Journal ArticleDOI
Visual Circuits for Direction Selectivity
TL;DR: This work reviews and compares recent progress in understanding the mechanisms that generate direction selectivity in the early visual system of mammals and flies and characterize neurons' upstream circuits in exquisite detail.
Population Code in Mouse V1 Facilities Read-out of Natural Scenes through Increased Sparseness
A Froudarakis,Philipp Berens,Alexander S. Ecker,RJ Cotton,Fabian H. Sinz,Dimitri Yatsenko,Peter Saggau,Matthias Bethge,Andreas S. Tolias +8 more
TL;DR: This article found that higher order correlations in natural scenes induced a sparser code, in which information is encoded by reliable activation of a smaller set of neurons and can be read out more easily.
Journal ArticleDOI
Co-transmission of acetylcholine and GABA regulates hippocampal states.
Virág T. Takács,Csaba Cserép,Dániel Schlingloff,Dániel Schlingloff,Balázs Pósfai,András Szonyi,András Szonyi,Katalin E. Sos,Katalin E. Sos,Zsuzsanna Környei,Adam Denes,Attila I. Gulyás,Tamás F. Freund,Gábor Nyiri +13 more
TL;DR: Cholinergic terminals juxtapose GABAergic synapses anatomically and functionally, and GABA and ACh molecules are co-transmitted, which suggests a hitherto unrecognised level of control over cortical states.
Journal Article
Subunit- and Pathway-Apecific Localization of NMDA Receptors and Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina
J. Zhang,J. S. Diamond +1 more
TL;DR: Postembedding immunogold electron microscopy techniques provide the first evidence for preferential association of particular NR1 splice variants, NR2 subunits, and MAGUKs at central synapses and suggest that different NMDAR subtypes may play specific roles at functionally distinct synapses in the retinal circuitry.
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Parallel Computations in Insect and Mammalian Visual Motion Processing.
Damon A. Clark,Jonathan B. Demb +1 more
TL;DR: This review compares how insect and mammalian neural circuits have solved the problem of motion estimation, focusing on the fruit fly Drosophila and the mouse retina and suggests that a limited set of algorithms for estimating motion satisfies both the needs of sighted creatures and the constraints imposed on them by metabolism, anatomy, and the structure and regularities of the visual world.
References
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Wiring specificity in the direction-selectivity circuit of the retina
TL;DR: It is shown, using serial block-face electron microscopy and two-photon calcium imaging, that the dendrites of mouse starburst amacrine cells make highly specific synapses with direction-selective ganglion cells depending on the ganglION cell’s preferred direction.
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Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors
Doris K. Patneau,Mark L. Mayer +1 more
TL;DR: Dose-response curves for activation of excitatory amino acid receptors on mouse embryonic hippocampal neurons in culture were recorded for 15 exciteatory amino acids, including the L-isomers of glutamate, aspartate, and a family of endogenous sulfur amino acids.
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S-potentials from luminosity units in the retina of fish (Cyprinidae)
K. I. Naka,W. A. H. Rushton +1 more
TL;DR: S‐potentials were recorded in fish from units which never responded by depolarization, and these hyperpolarizing units are the L‐units of Svaetichin & MacNichol (1958).
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Directionally selective calcium signals in dendrites of starburst amacrine cells
TL;DR: Dendritic calcium signals, but not somatic membrane voltage, are directionally selective for stimuli that move centrifugally from the cell soma, demonstrating that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells.
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Silent synapses and the emergence of a postsynaptic mechanism for LTP
TL;DR: Out of this literature has emerged a model for synapse unsilencing that highlights the central role for postsynaptic AMPA-receptor trafficking in the expression of excitatory synaptic plasticity.