Santhosh Sethuramanujam

TL;DR: A combination of paired patch-clamp recordings, serial EM, and large-scale multi-electrode array recordings are used to show that a single high-sensitivity source of glutamate is processed differentially by starbursts via AMPA receptors and DSGCs via NMDA receptors, which reveals a space-efficient synaptic circuit model for direction computations, in which "silent"NMDA receptors play critical roles.

TL;DR: In this article, the ultrastructural features of cholinergic connections between direction-selective starburst amacrine cells and downstream ganglion cells were characterized using electrophysiology and two-photon acetylcholine (ACh) imaging.

TL;DR: This work combines two-photon calcium imaging with genetic, pharmacological, and single-cell ablation methods to examine the extent to which inhibition ‘vetoes’ excitation at the level of individual dendrites of direction-selective ganglion cells and demonstrates that inhibition shapes direction selectivity independently within small dendritic segments with remarkable accuracy.

TL;DR: It is demonstrated that cAMP induced upregulation of the dependence receptor neogenin in the retina, exposing neogen in as a critical link between cAMP and photoreceptor death, and identifying a druggable target for the treatment of retinal degeneration.

TL;DR: In rat retina, starbursts were found to provide the major excitatory drive to a sub‐population of ganglion cells whose dendrite co‐stratify with starburst dendrites (putative DSGCs), while in mouse retina, recordings from genetically identified DS GCs at physiological temperatures reveal that ACh inputs dominate the response to small spot‐high contrast light stimuli.