S
Santiago Partida-Sanchez
Researcher at Nationwide Children's Hospital
Publications - 61
Citations - 4348
Santiago Partida-Sanchez is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 26, co-authored 61 publications receiving 3766 citations. Previous affiliations of Santiago Partida-Sanchez include The Research Institute at Nationwide Children's Hospital & Trudeau Institute.
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Journal ArticleDOI
Novel Markers to Delineate Murine M1 and M2 Macrophages
Kyle A. Jablonski,Stephanie A. Amici,Lindsay M. Webb,Juan de Dios Ruiz-Rosado,Phillip G. Popovich,Santiago Partida-Sanchez,Mireia Guerau-de-Arellano +6 more
TL;DR: Overall, this work defines exclusive and common M1 and M2 signatures and provides novel and improved tools to distinguish M1 or M2 murine macrophages.
Journal ArticleDOI
Migration of dendritic cell subsets and their precursors.
TL;DR: This work compares the distinct migratory patterns of plasmacytoid DCs (pDCs), CD8alpha(+) DCs, Langerhans cells, and conventional myeloid DCs and discusses how the highly regulated patterns of DC migration in vivo may affect their roles in immunity.
Journal ArticleDOI
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
Santiago Partida-Sanchez,Debra A. Cockayne,Simon Monard,Elaine L. Jacobson,Norman J. Oppenheimer,Beth A. Garvy,Kim Kusser,Stephen Goodrich,Maureen Howard,Allen G. Harmsen,Troy D. Randall,Frances E. Lund +11 more
TL;DR: It is demonstrated that neutrophil chemotaxis to bacterial chemoattractants is dependent on Ca++ mobilization mediated by cyclic ADP-ribose, and CD38 acts as a critical regulator of inflammation and innate immune responses.
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Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
Shabaana A. Khader,Santiago Partida-Sanchez,Guy K. Bell,Dawn M. Jelley-Gibbs,Susan L. Swain,John E. Pearl,Nico Ghilardi,Frederic Desauvage,Frances E. Lund,Andrea M. Cooper +9 more
TL;DR: A novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs is defined as restoring Mtb-induced DC migration and the ability of IL- 12p40–deficient DCs to activate naive T cells.
Journal ArticleDOI
TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.
Ingo Lange,Ingo Lange,Shinichiro Yamamoto,Santiago Partida-Sanchez,Santiago Partida-Sanchez,Yasuo Mori,Andrea Fleig,Andrea Fleig,Reinhold Penner,Reinhold Penner +9 more
TL;DR: It is reported that TRPM2, in addition to its role as a plasma membrane channel, also functions as a Ca2+-release channel activated by intracellular ADPR in a lysosomal compartment, which is critically linked to hydrogen peroxide–induced β cell death.