K
Kim Kusser
Researcher at Trudeau Institute
Publications - 20
Citations - 3314
Kim Kusser is an academic researcher from Trudeau Institute. The author has contributed to research in topics: Immune system & CCL21. The author has an hindex of 18, co-authored 20 publications receiving 3049 citations. Previous affiliations of Kim Kusser include University of Rochester Medical Center & University of Rochester.
Papers
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Journal ArticleDOI
Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity.
Juan Moyron-Quiroz,Javier Rangel-Moreno,Kim Kusser,Louise Hartson,Frank Sprague,Stephen Goodrich,David L. Woodland,Frances E. Lund,Troy D. Randall +8 more
TL;DR: It is shown that mice lacking spleen, lymph nodes and Peyer's patches generate unexpectedly robust primary B- and T-cell responses to influenza, which seem to be initiated at sites of induced BALT (iBALT), which functions as an inducible secondary lymphoid tissue for respiratory immune responses.
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Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo
Santiago Partida-Sanchez,Debra A. Cockayne,Simon Monard,Elaine L. Jacobson,Norman J. Oppenheimer,Beth A. Garvy,Kim Kusser,Stephen Goodrich,Maureen Howard,Allen G. Harmsen,Troy D. Randall,Frances E. Lund +11 more
TL;DR: It is demonstrated that neutrophil chemotaxis to bacterial chemoattractants is dependent on Ca++ mobilization mediated by cyclic ADP-ribose, and CD38 acts as a critical regulator of inflammation and innate immune responses.
Journal ArticleDOI
The development of inducible bronchus-associated lymphoid tissue depends on IL-17
Javier Rangel-Moreno,Damian M. Carragher,Maria de la Luz Garcia-Hernandez,Ji Young Hwang,Kim Kusser,Louise Hartson,Jay K. Kolls,Shabaana A. Khader,Troy D. Randall +8 more
TL;DR: It is found that interleukin 17 (IL-17) produced by CD4+ T cells was essential for the formation of iBALT, and this results suggest that IL-17-producing T cells are critical for the development of ectopic lymphoid tissues.
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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
Serge A. van de Pavert,Brenda J. Olivier,Gera Goverse,Mark F. R. Vondenhoff,Mascha Greuter,Patrick Beke,Kim Kusser,Uta E. Höpken,Martin Lipp,Karen Niederreither,Rune Blomhoff,Kasia Sitnik,William W. Agace,Troy D. Randall,Wouter J. de Jonge,Reina E. Mebius +15 more
TL;DR: The data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons, and show that parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CxCL13 in the gut.
Journal ArticleDOI
Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs
Juan Moyron-Quiroz,Javier Rangel-Moreno,Louise Hartson,Kim Kusser,Michael Tighe,Kimberly D. Klonowski,Leo Lefrançois,Linda S. Cauley,Allen G. Harmsen,Frances E. Lund,Troy D. Randall +10 more
TL;DR: It is found that influenza-specific CD8 cells in the lung acquired a memory phenotype, underwent homeostatic proliferation, recirculated through nonlymphoid tissues, and responded to and cleared a challenge infection in the complete absence of SLOs.