Antonio González-Pérez

TL;DR: Coxib use presents a lower RR of UGIB than non-selective NSAIDs, however, when combined with low-dose aspirin, the differences between non-selection NSAIDs and coxibs tend to disappear.

TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.

TL;DR: Antisecretory agent or nitrate treatment is associated with reduced UGIB RR in patients taking NSAID or aspirin, and protection was not apparent in patientsTaking anticoagulants.

TL;DR: The authors' APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region, and the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with TMEM106B (P=1·6 × 10−7) is noteworthy, because TMEM 106B variants have previously been associated with risk of frontotemporal dementia.

TL;DR: The results do not support the existence of a clinically meaningful interaction between aspirin and NSAIDs, including ibuprofen, including aspirin taken concomitantly.