Sara Knott

TL;DR: Methods for mapping QTL based on multiple regression which can be applied using any general statistical package are developed and it is shown that these regression methods produce very similar results to those obtained using maximum likelihood.

TL;DR: The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition, and the genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.

TL;DR: This paper developed a least square method for the analysis of crosses between outbred lines which simultaneously uses information from multiple linked markers, which is suitable for crosses where the lines may be segregating at marker loci but can be assumed to be fixed for alternative alleles at the major quantitative trait loci affecting the traits under analysis.

TL;DR: Genetic variants within a transporter gene, SLC2A9, that explain 1.7–5.3% of the variance in serum uric acid concentrations are identified following a genome-wide association scan in a Croatian population sample and it is shown that it has strong uric Acid transport activity in Xenopus laevis oocytes.

TL;DR: QTL Express is the first application for Quantitative Trait Locus mapping in outbred populations with a web-based user interface that allows mapping of single or multiple QTL by the regression approach, with the option to perform permutation or bootstrap tests.