Sara Salucci

TL;DR: Perisynaptic localization of NCX1-3 in dendrites and spines indicates that all isoforms are favourably located for buffering [Ca(2+)](i) in excitatory postsynaptic sites, as well as shaping astrocytic transients evoked by ongoing synaptic activity.

TL;DR: Investigating the effects of HyT and the corresponding ester hydroxytyrosyl laurate in U937 cells, a human monocytoid cell line, and in C2C12 myoblasts, a murine proliferating muscle cell model, after apoptotic death induction suggests these compounds as good candidate for novel therapeutic strategies.

TL;DR: Quantitative and qualitative immunocytochemical data suggest that all NCX isoforms contribute to mitochondrial Ca2+ homeostasis in neurons and glial cells in vivo, and that NCXs may be particularly involved in handling Ca1+ in dendritic, subplasmalemmal mitochondria, thus emphasizing the role of mitochondrial NCX1-3 in shaping postsynaptic calcium transients.

TL;DR: It is demonstrated that UVB radiation appears to be an ideal tool to study the apoptotic behavior in various cell models by using ultrastructural, molecular and cytofluorimetric techniques.

TL;DR: The results suggest that all conditions are able to induce apoptosis in C2C12 myoblasts, which occurs, considering trigger mechanisms of action, mostly following the mitochondrial pathway, if not excluding that due to DNA damage.