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Sarah C. Clarke
Researcher at Papworth Hospital
Publications - 51
Citations - 2809
Sarah C. Clarke is an academic researcher from Papworth Hospital. The author has contributed to research in topics: Percutaneous coronary intervention & Coronary artery disease. The author has an hindex of 15, co-authored 42 publications receiving 2509 citations.
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Journal ArticleDOI
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
Joanne Tracey Brindle,Henrik Antti,Elaine Holmes,George E. Tranter,Jeremy K. Nicholson,Hugh W.L. Bethell,Sarah C. Clarke,Peter R. Schofield,Elaine McKilligin,David E. Mosedale,David J. Grainger +10 more
TL;DR: These studies show for the first time a technique capable of providing an accurate, noninvasive and rapid diagnosis of coronary heart disease that can be used clinically, either in population screening or to allow effective targeting of treatments such as statins.
Journal ArticleDOI
Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease: The VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study
Patrick A. Calvert,Daniel R. Obaid,Daniel R. Obaid,Michael O'Sullivan,Leonard M. Shapiro,Duncan C. McNab,Cameron G. Densem,Peter R. Schofield,Denise Braganza,Sarah C. Clarke,Kausik K. Ray,Nick E.J. West,Martin R. Bennett +12 more
TL;DR: VH-IVUS TCFA was associated with nonrestenotic and total MACE on individual plaque analysis, and noncalcified VHTCFA wasassociated with nonRestenoticand total Mace on whole-patient analysis, demonstrating that VH- IVUS can identify plaques at increased risk of subsequent events.
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Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study A Prospective, Randomized Control Trial
Stephen P. Hoole,Patrick M. Heck,Linda D. Sharples,Sadia N. Khan,Rudolf Duehmke,Cameron G. Densem,Sarah C. Clarke,Leonard M. Shapiro,Peter R. Schofield,Michael O'Sullivan,David P. Dutka +10 more
TL;DR: Remote IPC reduces ischemic chest discomfort during PCI, attenuates procedure-related cTnI release, and appears to reduce subsequent cardiovascular events.
Journal ArticleDOI
Proton NMR analysis of plasma is a weak predictor of coronary artery disease.
Heide L. Kirschenlohr,Julian L. Griffin,Sarah C. Clarke,Ranyl Rhydwen,Andrew A. Grace,Andrew A. Grace,Peter R. Schofield,Kevin M. Brindle,James C. Metcalfe +8 more
TL;DR: Predicting angiographically defined advanced coronary artery disease with >90% accuracy and specificity using plasma samples from groups of male patients, classified by statin treatment, who had normal coronary arteries (NCAs) or CAD is determined.
Journal ArticleDOI
Leukocyte Telomere Length Is Associated With High-Risk Plaques on Virtual Histology Intravascular Ultrasound and Increased Proinflammatory Activity
Patrick A. Calvert,Tze-Vun Liew,Isabelle Gorenne,Murray C.H. Clarke,Charis Costopoulos,Daniel R. Obaid,Michael O'Sullivan,Leonard M. Shapiro,Duncan C. McNab,Cameron G. Densem,Peter R. Schofield,Denise Braganza,Sarah C. Clarke,Kausik K. Ray,Nick E.J. West,Martin R. Bennett +15 more
TL;DR: Shorter LTL is associated with high-risk plaque morphology on virtual histology intravascular ultrasound but not total 3-vessel plaque burden, suggesting that telomere shortening promotes high- risk plaque subtypes by increasing proinflammatory activity.