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Sarah C. Sasson
Researcher at University of Oxford
Publications - 47
Citations - 2447
Sarah C. Sasson is an academic researcher from University of Oxford. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 12, co-authored 32 publications receiving 2094 citations. Previous affiliations of Sarah C. Sasson include Concord Hospital & University of Sydney.
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Journal ArticleDOI
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
Nabila Seddiki,Nabila Seddiki,Brigitte Santner-Nanan,Jeff Martinson,John Zaunders,Sarah C. Sasson,Alan L. Landay,Michael J. Solomon,Warwick Selby,Stephen I. Alexander,Ralph Nanan,Anthony D. Kelleher,Barbara Fazekas de St Groth +12 more
TL;DR: Cell surface expression of CD127 allows accurate estimation of T reg cell numbers and isolation of pure populations for in vitro studies and should contribute to the understanding of regulatory abnormalities in immunopathic diseases.
Journal ArticleDOI
Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease.
Nabila Seddiki,Nabila Seddiki,Sarah C. Sasson,Sarah C. Sasson,Brigitte Santner-Nanan,Mee Ling Munier,Mee Ling Munier,David van Bockel,David van Bockel,Susanna Ip,Susanna Ip,Deborah Marriott,Sarah Pett,Ralph Nanan,David A. Cooper,David A. Cooper,John Zaunders,Anthony D. Kelleher,Anthony D. Kelleher +18 more
TL;DR: The data suggest that despite substantial Treg expansion in IRD, their ability to induce suppression, and thereby downregulate aberrant immune responses, is compromised.
Journal ArticleDOI
Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.
Sarah C. Sasson,John Zaunders,Giulia Zanetti,Eleanor M King,Kate Merlin,Don Smith,Keith K. Stanley,David A. Cooper,Anthony D. Kelleher +8 more
TL;DR: Perturbations in the IL-7/IL-7R system were clearly associated with disease progression but did not reliably predict immune reconstitution.
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Infection of CD127+ (Interleukin-7 Receptor+) CD4+ Cells and Overexpression of CTLA-4 Are Linked to Loss of Antigen-Specific CD4 T Cells during Primary Human Immunodeficiency Virus Type 1 Infection
John Zaunders,Susanna Ip,Susanna Ip,Mee Ling Munier,Mee Ling Munier,Daniel Kaufmann,Kazuo Suzuki,Choechoe Brereton,Sarah C. Sasson,Sarah C. Sasson,Nabila Seddiki,Kersten K. Koelsch,Kersten K. Koelsch,Alan L. Landay,Pat Grey,Robert Finlayson,John M. Kaldor,Eric S. Rosenberg,Bruce D. Walker,Barbara Fazekas de St Groth,David A. Cooper,David A. Cooper,Anthony D. Kelleher,Anthony D. Kelleher +23 more
TL;DR: The loss of HIV-specific CD4- T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4.
Journal ArticleDOI
The IL-7/IL-7 Receptor Axis: Understanding its Central Role in T-Cell Homeostasis and the Challenges Facing its Utilization as a Novel Therapy
TL;DR: Important considerations such as the possible negative impacts of IL-7 on increased viral infectivity, the induction of autoimmunity and risk of neoplastic events are discussed.