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Barbara Fazekas de St Groth
Researcher at University of Sydney
Publications - 108
Citations - 10730
Barbara Fazekas de St Groth is an academic researcher from University of Sydney. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 36, co-authored 103 publications receiving 9981 citations. Previous affiliations of Barbara Fazekas de St Groth include Walter and Eliza Hall Institute of Medical Research & Centenary Institute of Cancer Medicine and Cell Biology.
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Journal ArticleDOI
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Weihong Liu,Amy L. Putnam,Zhou Xu-yu,Gregory L. Szot,Michael R. Lee,Shirley Zhu,Peter A. Gottlieb,Philipp Kapranov,Thomas R. Gingeras,Barbara Fazekas de St Groth,Carol Clayberger,David M. Soper,Steven F. Ziegler,Jeffrey A. Bluestone +13 more
TL;DR: It is found that the IL-7 receptor (CD127) is down-regulated on a subset of CD4+ T cells in peripheral blood and can be used to quantitate T reg cell subsets in individuals with type 1 diabetes supporting the use of CD127 as a biomarker for human T reg cells.
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Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
Nabila Seddiki,Nabila Seddiki,Brigitte Santner-Nanan,Jeff Martinson,John Zaunders,Sarah C. Sasson,Alan L. Landay,Michael J. Solomon,Warwick Selby,Stephen I. Alexander,Ralph Nanan,Anthony D. Kelleher,Barbara Fazekas de St Groth +12 more
TL;DR: Cell surface expression of CD127 allows accurate estimation of T reg cell numbers and isolation of pure populations for in vitro studies and should contribute to the understanding of regulatory abnormalities in immunopathic diseases.
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Cellular and genetic mechanisms of self tolerance and autoimmunity
TL;DR: The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body, and cellular mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve immunological self tolerance.
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Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics.
TL;DR: Charge substitutions on the peptide often elicit reciprocal charges in the junctional sequences of T-cell receptor Vαor Vβ chains, indicating direct T- Cell receptor–peptide contact, and allowing derivation of a topology for the T- cell receptor–MHC interaction.
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Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
Ben Roediger,Ryan Kyle,Kwok Ho Yip,Nital Sumaria,Nital Sumaria,Thomas V. Guy,Brian S. Kim,Andrew J. Mitchell,Szun S. Tay,Rohit Jain,Elizabeth Forbes-Blom,Xi Chen,Philip L. Tong,Philip L. Tong,Philip L. Tong,Holly A. Bolton,David Artis,William E. Paul,Barbara Fazekas de St Groth,Barbara Fazekas de St Groth,Michele A. Grimbaldeston,Graham Le Gros,Wolfgang Weninger,Wolfgang Weninger,Wolfgang Weninger +24 more
TL;DR: The data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.