S
Stephen I. Alexander
Researcher at Children's Hospital at Westmead
Publications - 212
Citations - 9951
Stephen I. Alexander is an academic researcher from Children's Hospital at Westmead. The author has contributed to research in topics: Transplantation & Kidney. The author has an hindex of 42, co-authored 206 publications receiving 8530 citations. Previous affiliations of Stephen I. Alexander include Boston Children's Hospital & Children's Medical Research Institute.
Papers
More filters
Journal ArticleDOI
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
Nabila Seddiki,Nabila Seddiki,Brigitte Santner-Nanan,Jeff Martinson,John Zaunders,Sarah C. Sasson,Alan L. Landay,Michael J. Solomon,Warwick Selby,Stephen I. Alexander,Ralph Nanan,Anthony D. Kelleher,Barbara Fazekas de St Groth +12 more
TL;DR: Cell surface expression of CD127 allows accurate estimation of T reg cell numbers and isolation of pure populations for in vitro studies and should contribute to the understanding of regulatory abnormalities in immunopathic diseases.
Journal ArticleDOI
TLR4 activation mediates kidney ischemia/reperfusion injury
Huiling Wu,Gang Chen,Kate Wyburn,Jianlin Yin,Patrick Bertolino,Josette Eris,Stephen I. Alexander,Alexandra F. Sharland,Steven J. Chadban +8 more
TL;DR: Using a mouse model of kidney IRI, a significant increase in TLR4 expression by tubular epithelial cells (TECs) and infiltrating leukocytes within the kidney following ischemia is demonstrated, suggesting thatTLR4 signaling in intrinsic kidney cells plays the dominant role in mediating kidney damage.
Journal ArticleDOI
Rejection of the kidney allograft.
TL;DR: This review gives an account of the current understanding of the mechanisms of rejection of renal allografts, and new immunosuppressive agents show promise, but graft survival beyond 5 years has not improved substantially.
Journal ArticleDOI
Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease
Ya Wang,Yiping Wang,Guoping Zheng,Vincent W. Lee,L. Ouyang,D. H. H. Chang,Deepika Mahajan,J. Coombs,Yuan M. Wang,Stephen I. Alexander,David Harris +10 more
TL;DR: It is demonstrated that macrophages not only act as effectors of immune injury but can be induced to provide protection against immune injury.
Journal ArticleDOI
Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction.
John P. Vella,Monica Spadafora-Ferreira,Barbara Murphy,Stephen I. Alexander,William E. Harmon,Charles B. Carpenter,Mohamed H. Sayegh +6 more
TL;DR: The hypothesis that T cells primed via the indirect pathway of allorecognition may be important mediators of chronic rejection is supported and the rationale to develop specific therapeutic strategies to prevent or interrupt this process is provided.