S
Sarah E. McClelland
Researcher at Queen Mary University of London
Publications - 34
Citations - 2256
Sarah E. McClelland is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Chromosome instability & Cancer. The author has an hindex of 12, co-authored 27 publications receiving 1934 citations. Previous affiliations of Sarah E. McClelland include London Research Institute.
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Replication stress links structural and numerical cancer chromosomal instability
Rebecca A. Burrell,Sarah E. McClelland,David Endesfelder,Petra Groth,Marie-Christine Weller,Nadeem Shaikh,Enric Domingo,Nnennaya Kanu,Sally M. Dewhurst,Eva Grönroos,Su Kit Chew,Andrew Rowan,Arne Schenk,Michal Sheffer,Michael Howell,Maik Kschischo,Axel Behrens,Thomas Helleday,Jiri Bartek,Ian Tomlinson,Charles Swanton +20 more
TL;DR: Evidence for impaired replication fork progression and increased DNA replication stress in CIN+ colorectal cancer (CRC) cells relative to CIN− CRC cells is found, with structural chromosome abnormalities precipitating chromosome missegregation in mitosis.
Journal ArticleDOI
Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)
Rebecca A. Burrell,Sarah E. McClelland,David Endesfelder,Petra Groth,Marie-Christine Weller,Nadeem Shaikh,Enric Domingo,Nnennaya Kanu,Sally M. Dewhurst,Eva Grönroos,Su Kit Chew,Andrew Rowan,Arne Schenk,Michal Sheffer,Michael Howell,Maik Kschischo,Axel Behrens,Thomas Helleday,Jiri Bartek,Ian Tomlinson,Charles Swanton +20 more
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Paradoxical relationship between chromosomal instability and survival outcome in cancer.
Nicolai Juul Birkbak,Aron Charles Eklund,Qiyuan Li,Qiyuan Li,Sarah E. McClelland,David Endesfelder,Patrick Tan,Iain Beehuat Tan,Andrea L. Richardson,Zoltan Szallasi,Zoltan Szallasi,Charles Swanton,Charles Swanton +12 more
TL;DR: A nonmonotonic relationship between gene signature expression and HR for survival outcome is suggested, which may explain the difficulties encountered in the identification of prognostic expression signatures in ER(-) breast cancer.
Journal ArticleDOI
Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy
TL;DR: A common theme emerging from studies is that CIN may be a multi-layered phenotype comprising an increased propensity to missegregate chromosomes during mitosis and a survival state specifically adapted to aneuploidy, frequent aberrant mitoses and the constant reshuffling of the genome.
A composite phenotype that influences sensitivity to chemotherapy
TL;DR: Swanton et al. as mentioned in this paper found that CIN may be a multi-layered phenotype comprising an increased propensity to missegregate chromosomes during mitosis and a survival state specifically adapted to aneuploidy, frequent aberrant mitoses and the constant reshuffling of the genome.