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Iain Beehuat Tan
Researcher at National University of Singapore
Publications - 125
Citations - 8906
Iain Beehuat Tan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 38, co-authored 113 publications receiving 6891 citations. Previous affiliations of Iain Beehuat Tan include Agency for Science, Technology and Research & Genome Institute of Singapore.
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Journal ArticleDOI
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Yannick Simoni,Etienne Becht,Michael G. Fehlings,Chiew Yee Loh,Si-Lin Koo,Karen Wei Weng Teng,Joe Poh Sheng Yeong,Joe Poh Sheng Yeong,Rahul Nahar,Tong Zhang,Hassen Kared,Kaibo Duan,Nicholas Ang,Michael Poidinger,Yin Yeng Lee,Anis Larbi,Alexis Jiaying Khng,Emile Tan,Cherylin Fu,Ronnie Mathew,Melissa Ching Ching Teo,Wan-Teck Lim,Chee Keong Toh,Boon-Hean Ong,Tina Koh,Axel M. Hillmer,Angela Takano,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Tony Kiat-Hon Lim,Eng Huat Tan,Weiwei Zhai,Daniel Shao-Weng Tan,Daniel Shao-Weng Tan,Iain Beehuat Tan,Iain Beehuat Tan,Iain Beehuat Tan,Evan W. Newell +37 more
TL;DR: It is shown that human lung and colorectal cancer CD8+ TILs can not only be specific for tumour antigens, but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein–Barr virus, human cytomegalovirus or influenza virus).
Journal ArticleDOI
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Huipeng Li,Elise T. Courtois,Debarka Sengupta,Debarka Sengupta,Yuliana Tan,Kok Hao Chen,Jolene Jie Lin Goh,Say Li Kong,Clarinda Chua,Lim Kiat Hon,Wah Siew Tan,Mark T. C. Wong,Paul Jongjoon Choi,Lawrence J K Wee,Axel M. Hillmer,Iain Beehuat Tan,Iain Beehuat Tan,Paul Robson,Shyam Prabhakar +18 more
TL;DR: The results demonstrate that unbiased single-cell RNA–seq profiling of tumor and matched normal samples provides a unique opportunity to characterize aberrant cell states within a tumor.
Journal ArticleDOI
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
Zhi Jiang Zang,Ioana Cutcutache,Song Ling Poon,Shen Li Zhang,John R. McPherson,Jiong Tao,Vikneswari Rajasegaran,Hong Lee Heng,Niantao Deng,Anna Gan,Kiat Hon Lim,Choon Kiat Ong,Dachuan Huang,Sze Yung Chin,Iain Beehuat Tan,Cedric Chuan Young Ng,Willie Yu,Yingting Wu,Minghui Lee,Jeanie Wu,Dianne Poh,Wei Keat Wan,Sun Young Rha,Jimmy Bok Yan So,Manuel Salto-Tellez,Manuel Salto-Tellez,Khay Guan Yeoh,Wai-Keong Wong,Yi Jun Zhu,P. Andrew Futreal,Brendan Pang,Yijun Ruan,Axel M. Hillmer,Denis Bertrand,Niranjan Nagarajan,Steve Rozen,Bin Tean Teh,Bin Tean Teh,Patrick Tan,Patrick Tan +39 more
TL;DR: Somatic inactivation of FAT4 and ARID1A may be key tumorigenic events in a subset of gastric cancers, and cell adhesion was the most enriched biological pathway among the frequently mutated genes.
Journal ArticleDOI
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
Niantao Deng,Liang Kee Goh,Hannah Wang,Kakoli Das,Jiong Tao,Iain Beehuat Tan,Shenli Zhang,Minghui Lee,Jeanie Wu,Kiat Hon Lim,Zhengdeng Lei,Glenn Goh,Qing-Yan Lim,Angie Lay-Keng Tan,Dianne Yu Sin Poh,Sudep Riahi,Sandra M. Bell,Michael M. Shi,Ronald Linnartz,Feng-Cai Zhu,Khay Guan Yeoh,Han Chong Toh,Wei Peng Yong,Hyun Cheol Cheong,Sun Young Rha,Alex Boussioutas,Heike Grabsch,Steve Rozen,Patrick Tan +28 more
TL;DR: The study demonstrates the existence of five distinct gastric cancer patient subgroups, defined by the signature genomic alterations FGFR2 (9% of tumours), KRAS (9%), EGFR (8%), ERBB2 (7%) and MET (4%).
Journal ArticleDOI
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.