Sarah E. St. John

TL;DR: Targeting papain-like protease with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.

TL;DR: Activation of Mers-CoV 3CLpro through ligand-induced dimerization appears to be unique within the genogroup 2c and may potentially increase the complexity in the development of MERS- coV 3clpro inhibitors as antiviral agents.

TL;DR: The X-ray structures and SAR analysis reveal critical insights into the structure and inhibition of HKU4-CoV 3CLpro, providing fundamental knowledge that may be exploited in the development of anti-coronaviral therapeutics for coronaviruses emerging from zoonotic reservoirs.

TL;DR: Several novel inhibitors of QR2 were successfully identified as well as a compound that inhibits QR2 with a novel binding orientation, which may protect cells against reactive intermediates and eventually cancer.

TL;DR: The first X-ray crystal structure of FIPV-3CLpro in complex with the best inhibitor identified is determined to better understand the structural basis for inhibitor specificity and expands the current structural knowledge of coronaviral 3CLpro architecture.