Sarah J. Plummer

TL;DR: Data provided for the first demonstration that xenotropic MuLV-related viruses can produce an authentic human infection, and strongly implicate RNase L activity in the prevention or clearance of infection in vivo, raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals.

TL;DR: The RNASEL variant Arg462Gln has three times less enzymatic activity than the wildtype and is significantly associated with prostate cancer risk and at least one copy of the mutated allele that causes this substitution is carried by nearly 60% of the men in this study.

TL;DR: It is concluded that a combination of DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known alterations in the p53 gene in human malignancies.

TL;DR: Findings support the notion that RNASEL mutations and some variants allow tumor cells to escape a potent apoptotic pathway.

TL;DR: The findings indicate that the distinction between an MSI-H phenotype from a low-instability or MSS phenotype can best be accomplished by using a cutoff of 30% or greater of the markers showing instability.