S
Sarah L. Parylak
Researcher at Salk Institute for Biological Studies
Publications - 17
Citations - 2121
Sarah L. Parylak is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Neurogenesis & Dentate gyrus. The author has an hindex of 11, co-authored 16 publications receiving 1434 citations.
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Journal ArticleDOI
An in vivo model of functional and vascularized human brain organoids
Abed AlFatah Mansour,J. Tiago Gonçalves,Cooper W Bloyd,Hao Li,Sarah Fernandes,Sarah Fernandes,Daphne Quang,Stephen T. Johnston,Sarah L. Parylak,Xin Jin,Fred H. Gage +10 more
TL;DR: A method for transplanting human brain organoids into the adult mouse brain is established and progressive neuronal differentiation and maturation, gliogenesis, integration of microglia, and growth of axons to multiple regions of the host brain are shown.
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The role of adult hippocampal neurogenesis in brain health and disease
TL;DR: A possible link between the physiological functions of adult-born neurons and their roles in pathological conditions is reviewed.
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Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Benjamin Lacar,Sara B. Linker,Baptiste N. Jaeger,Suguna Rani Krishnaswami,Jerika J. Barron,Martijn J. E. Kelder,Sarah L. Parylak,Apuã C. M. Paquola,Pratap Venepally,Mark Novotny,Carolyn O’Connor,Conor Fitzpatrick,Jennifer A. Erwin,Jonathan Y. Hsu,David Husband,Michael J. McConnell,Roger S. Lasken,Fred H. Gage +17 more
TL;DR: It is shown that snRNA-seq faithfully recapitulates transcriptional patterns associated with experience-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1, allowing for novel insights into neuronal activation patterns in vivo.
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Correction: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Benjamin Lacar,Sara B. Linker,Baptiste N. Jaeger,Suguna Rani Krishnaswami,Jerika J. Barron,Martijn J. E. Kelder,Sarah L. Parylak,Apuã C. M. Paquola,Pratap Venepally,Mark Novotny,Carolyn O’Connor,Conor Fitzpatrick,Jennifer A. Erwin,Jonathan Y. Hsu,David Husband,Michael J. McConnell,Roger S. Lasken,Fred H. Gage +17 more
TL;DR: Krishnaswami et al. as discussed by the authors omitted the middle names or initials of the authors from the author information, which was later changed to the middle name of the paper.
Journal ArticleDOI
In vivo imaging of dendritic pruning in dentate granule cells
J. Tiago Gonçalves,Cooper W Bloyd,Matthew Shtrahman,Stephen T. Johnston,Simon T. Schafer,Sarah L. Parylak,Thanh Tran,Tina Chang,Fred H. Gage +8 more
TL;DR: The longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells in vivo and found that they underwent over-branching and pruning, indicating that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.