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Sarah L. Parylak

Researcher at Salk Institute for Biological Studies

Publications -  17
Citations -  2121

Sarah L. Parylak is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Neurogenesis & Dentate gyrus. The author has an hindex of 11, co-authored 16 publications receiving 1434 citations.

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An in vivo model of functional and vascularized human brain organoids

TL;DR: A method for transplanting human brain organoids into the adult mouse brain is established and progressive neuronal differentiation and maturation, gliogenesis, integration of microglia, and growth of axons to multiple regions of the host brain are shown.
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The role of adult hippocampal neurogenesis in brain health and disease

TL;DR: A possible link between the physiological functions of adult-born neurons and their roles in pathological conditions is reviewed.
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Nuclear RNA-seq of single neurons reveals molecular signatures of activation

TL;DR: It is shown that snRNA-seq faithfully recapitulates transcriptional patterns associated with experience-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1, allowing for novel insights into neuronal activation patterns in vivo.
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In vivo imaging of dendritic pruning in dentate granule cells

TL;DR: The longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells in vivo and found that they underwent over-branching and pruning, indicating that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.