Sara B. Linker

TL;DR: A possible link between the physiological functions of adult-born neurons and their roles in pathological conditions is reviewed.

TL;DR: A protocol is described for sequencing the transcriptome of a cell nucleus by isolating nuclei at 4 °C from tissue homogenates, which cause minimal damage and allows investigation of biological features unique to nuclei, such as enrichment of certain transcripts and precursors of some noncoding RNAs.

TL;DR: It is shown that snRNA-seq faithfully recapitulates transcriptional patterns associated with experience-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1, allowing for novel insights into neuronal activation patterns in vivo.

TL;DR: Krishnaswami et al. as discussed by the authors omitted the middle names or initials of the authors from the author information, which was later changed to the middle name of the paper.

TL;DR: In this paper, the authors discuss new evidence and ideas that the activity of retrotransposons, a major subgroup of transposons overall, influences and even promotes the process of ageing and age-related diseases in complex metazoan organisms, including humans.