Conor Fitzpatrick

TL;DR: The transcriptomes and DNA regulatory elements of human microglia ex vivo and in vitro in comparison to the mouse are defined and systematically relate these features to expression of genes associated with genome-wide association study (GWAS) risk alleles or exhibiting altered expression in neurodegenerative diseases and psychiatric disorders.

TL;DR: It is shown that snRNA-seq faithfully recapitulates transcriptional patterns associated with experience-driven induction of activity, including immediate early genes (IEGs) such as Fos, Arc and Egr1, allowing for novel insights into neuronal activation patterns in vivo.

TL;DR: Krishnaswami et al. as discussed by the authors omitted the middle names or initials of the authors from the author information, which was later changed to the middle name of the paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: Single-nucleus methyl-3C sequencing jointly interrogates 3D chromatin organization and DNA methylation in human cells, and these joint measurements more accurately distinguish different cell types than either unimodal method.