A
Arlene Hurley
Researcher at Rockefeller University
Publications - 63
Citations - 17740
Arlene Hurley is an academic researcher from Rockefeller University. The author has contributed to research in topics: Virus & Antibody. The author has an hindex of 43, co-authored 62 publications receiving 14505 citations. Previous affiliations of Arlene Hurley include Los Alamos National Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
Decay characteristics of HIV-1-infected compartments during combination therapy
Alan S. Perelson,Paulina Essunger,Yunzhen Cao,Mika Vesanen,Arlene Hurley,Kalle Saksela,Martin Markowitz,David D. Ho +7 more
TL;DR: It is estimated that 2.3–3.1 years of a completely inhibitory treatment would be required to eliminate HIV-1 from these compartments, and even longer treatment may be needed because of the possible existence of undetected viral compartments or sanctuary sites.
Journal ArticleDOI
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
Davide F. Robbiani,Davide F. Robbiani,Christian Gaebler,Frauke Muecksch,Julio C. C. Lorenzi,Zijun Wang,Alice Cho,Marianna Agudelo,Christopher O. Barnes,Anna Gazumyan,Shlomo Finkin,Thomas Hagglof,Thiago Y. Oliveira,Charlotte Viant,Arlene Hurley,Hans Heinrich Hoffmann,Katrina G. Millard,Rhonda G. Kost,Melissa Cipolla,Kristie Gordon,Filippo Bianchini,Spencer T. Chen,Victor A. Ramos,Roshni Patel,Juan Dizon,Irina Shimeliovich,Pilar Mendoza,Harald Hartweger,Lilian Nogueira,Maggi Pack,Jill Horowitz,Fabian Schmidt,Yiska Weisblum,Eleftherios Michailidis,Alison W. Ashbrook,Eric Waltari,John E. Pak,Kathryn E. Huey-Tubman,Nicholas Koranda,Pauline R. Hoffman,Anthony P. West,Charles M. Rice,Theodora Hatziioannou,Pamela J. Bjorkman,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +48 more
TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.
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Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Graham S. Ogg,Xia Jin,Sebastian Bonhoeffer,P R Dunbar,Martin A. Nowak,Simon Monard,Jeremy P. Segal,Yunzhen Cao,Sarah Rowland-Jones,Vincenzo Cerundolo,Arlene Hurley,M. Markowitz,David D. Ho,Douglas F. Nixon,Andrew J. McMichael +14 more
TL;DR: With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load and suggest a considerable cytopathic effect of the virus in vivo.
Journal ArticleDOI
Evolution of antibody immunity to SARS-CoV-2.
Christian Gaebler,Zijun Wang,Julio C. C. Lorenzi,Frauke Muecksch,Shlomo Finkin,Minami Tokuyama,Alice Cho,Mila Jankovic,Dennis Schaefer-Babajew,Thiago Y. Oliveira,Melissa Cipolla,Charlotte Viant,Christopher O. Barnes,Yaron Bram,Gaëlle Breton,Thomas Hagglof,Pilar Mendoza,Arlene Hurley,Martina Turroja,Kristie Gordon,Katrina G. Millard,Victor A. Ramos,Fabian Schmidt,Yiska Weisblum,Divya Jha,Michael Tankelevich,Gustavo Martinez-Delgado,Jim Yee,Roshni Patel,Juan Dizon,Cecille Unson-O'Brien,Irina Shimeliovich,Davide F. Robbiani,Zhen Zhao,Anna Gazumyan,Robert E. Schwartz,Theodora Hatziioannou,Pamela J. Bjorkman,Saurabh Mehandru,Paul D. Bieniasz,Paul D. Bieniasz,Marina Caskey,Michel C. Nussenzweig,Michel C. Nussenzweig +43 more
TL;DR: In this article, the authors report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection with SARS-CoV-2.
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Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract.
Saurabh Mehandru,Michael A. Poles,Michael A. Poles,Klara Tenner-Racz,Amir Horowitz,Amir Horowitz,Arlene Hurley,Christine Hogan,Daniel Boden,Paul Racz,Martin Markowitz +10 more
TL;DR: It is demonstrated that although chronic suppression of HIV-1 permits near-complete immune recovery of the peripheral blood CD4+ T cell population, a significantly greater CD4- T cell loss remains in the GI mucosa, despite up to 5 yr of fully suppressive therapy.