J
James M. Binley
Researcher at Aaron Diamond AIDS Research Center
Publications - 60
Citations - 9708
James M. Binley is an academic researcher from Aaron Diamond AIDS Research Center. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 42, co-authored 59 publications receiving 9384 citations. Previous affiliations of James M. Binley include New York University & Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
Alexandra Trkola,Tatjana Dragic,James Arthos,James M. Binley,William C. Olson,Graham P. Allaway,Cecilia Cheng-Mayer,James E. Robinson,Paul J. Maddon,John P. Moore +9 more
TL;DR: CD4 binding, although not absolutely necessary for the gp120–CCR-5 interaction, greatly increases its efficiency, and interference with HIV-1 binding to one or both of its receptors (CD4 and CCR-5) may be an important mechanism of virus neutralization.
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Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.
Michael B. Zwick,Aran F. Labrijn,Min Wang,Catherine Spenlehauer,Erica Ollmann Saphire,James M. Binley,John P. Moore,Gabriela Stiegler,Hermann Katinger,Dennis R. Burton,Paul W. H. I. Parren +10 more
TL;DR: The results suggest that a rather extensive region of gp41 close to the transmembrane domain is accessible to neutralizing Abs and could form a useful target for vaccine design.
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Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies
James M. Binley,Terri Wrin,Bette T. Korber,Michael B. Zwick,Min Wang,Colombe Chappey,Gabriela Stiegler,Renate Kunert,Susan Zolla-Pazner,Hermann Katinger,Christos J. Petropoulos,Dennis R. Burton +11 more
TL;DR: Broadly neutralizing monoclonal antibodies are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design and have implications for passive-immunization studies in countries where clade C viruses are common, given that only MAbs b12 and 4E10 were effective against viruses from this clade.
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A Recombinant Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Complex Stabilized by an Intermolecular Disulfide Bond between the gp120 and gp41 Subunits Is an Antigenic Mimic of the Trimeric Virion-Associated Structure
James M. Binley,Rogier W. Sanders,Brian Clas,Norbert Schuelke,Aditi Master,Yong Guo,Francis Kajumo,Deborah J. Anselma,Paul J. Maddon,William C. Olson,John P. Moore +10 more
TL;DR: A disulfide bond is introduced between the C-terminal region of gp120 and the immunodominant segment of the gp41 ectodomain, producing a properly folded envelope glycoprotein complex which has antigenic properties which resemble those of the virion-associated complex.
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Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis
Bharat Ramratnam,Sebastian Bonhoeffer,James M. Binley,Arlene Hurley,Linqi Zhang,John E. Mittler,Martin Markowitz,John P. Moore,Alan S. Perelson,David D. Ho +9 more
TL;DR: It is confirmed that HIV-1 and HCV are produced and cleared extremely rapidly, up to ten times higher than previous estimates, whereas HCV clearance is similar to previous estimates.