Sarah S K Yue

TL;DR: A primary gastric cancer organoid biobank that comprises normal, dysplastic, cancer, and lymph node metastases from 34 patients, including detailed whole-exome and transcriptome analysis, provides a useful resource for studying both cancer cell biology and precision cancer therapy.

TL;DR: The importance of RNF43, along with BRAF mutation in the serrated neoplasia pathway is illustrated to inform genetic diagnosis protocol and raise therapeutic opportunities through Wnt inhibition in different stages of evolution of serrated polyps.

TL;DR: These organoid models enriched in EOCRCs with linked genomic data fill a gap in existing CRC models and reveal distinct genetic profiles and novel pathway cooperativity.

TL;DR: In this article , a whole genome sequence of 152 colonic crypts from normal and neoplastic epithelial tissues from 10 Lynch Syndrome (LS) patients was used to demonstrate the genomic stability of epithelial cells with heterozygous germline MMR gene mutations.

TL;DR: In this article , a whole genome sequence of 152 colonic crypts from normal and neoplastic epithelial tissues from 10 Lynch Syndrome (LS) patients was used to demonstrate the genomic stability of epithelial cells with heterozygous germline MMR gene mutations.