J
Jiangwen Zhang
Researcher at University of Hong Kong
Publications - 66
Citations - 11875
Jiangwen Zhang is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Cancer & Adipogenesis. The author has an hindex of 41, co-authored 62 publications receiving 9790 citations. Previous affiliations of Jiangwen Zhang include Johns Hopkins University School of Medicine & Harvard University.
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Journal ArticleDOI
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
Laura Poliseno,Leonardo Salmena,Jiangwen Zhang,Brett S. Carver,William J. Haveman,Pier Paolo Pandolfi +5 more
TL;DR: It is found that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role, and this analysis extended to other cancer-related genes that possess pseudogenes, and revealed a non-coding function for mRNAs.
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The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing
TL;DR: Neuron-specific microRNA miR-124 promotes NS development, at least in part by regulating an intricate network of NS-specific alternative splicing patterns.
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TISIDB: an integrated repository portal for tumor-immune system interactions
Beibei Ru,CN Wong,Yin Tong,Jia Yi Zhong,Sophia Shek Wa Zhong,Wai Chung Wu,Ka Chi Chu,Choi Yiu Wong,Chit Ying Lau,Ian Chen,Nam Wai Chan,Jiangwen Zhang +11 more
TL;DR: A user-friendly web portal TISIDB is designed, which integrated multiple types of data resources in oncoimmunology, and biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis.
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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
Lydia W.S. Finley,Arkaitz Carracedo,Jaewon J. Lee,Amanda Souza,Ainara Egia,Jiangwen Zhang,Julie Teruya-Feldstein,Paula I. Moreira,Sandra M. Cardoso,Clary B. Clish,Pier Paolo Pandolfi,Marcia C. Haigis +11 more
TL;DR: It is shown that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect, and it is found that Sirt3 overexpression represses glycolysis and proliferation in breast cancer cells, providing a metabolic mechanism for tumor suppression.
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Subtle variations in Pten dose determine cancer susceptibility
Andrea Alimonti,Arkaitz Carracedo,John G. Clohessy,Lloyd C. Trotman,Lloyd C. Trotman,Caterina Nardella,Ainara Egia,Leonardo Salmena,Katia Sampieri,William J. Haveman,Edi Brogi,Andrea L. Richardson,Jiangwen Zhang,Pier Paolo Pandolfi +13 more
TL;DR: An alterative working model for cancer development is presented in which subtle reductions in the dose of TSGs predispose to tumorigenesis in a tissue-specific manner and subtle downregulation of Pten altered the steady-state biology of the mammary tissues and the expression profiles of genes involved in cancer cell proliferation.