S
Sarah Sanowar
Researcher at Genentech
Publications - 15
Citations - 1155
Sarah Sanowar is an academic researcher from Genentech. The author has contributed to research in topics: Bacterial outer membrane & Periplasmic space. The author has an hindex of 11, co-authored 14 publications receiving 1075 citations. Previous affiliations of Sarah Sanowar include University of Washington & McGill University.
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Journal ArticleDOI
Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Martin Bader,Sarah Sanowar,Margaret E. Daley,Anna Schneider,Uhn-Soo Cho,Wenqing Xu,Rachel E. Klevit,Hervé Le Moual,Samuel I. Miller +8 more
TL;DR: It is shown that enzymatic activity of Salmonella typhimurium PhoQ is directly activated by antimicrobial peptides.
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A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system
Thomas Spreter,Calvin K. Yip,Calvin K. Yip,Sarah Sanowar,Ingemar André,Tyler G. Kimbrough,Tyler G. Kimbrough,Marija Vuckovic,Richard A. Pfuetzner,Wanyin Deng,Angel C. Yu,B. Brett Finlay,David Baker,Samuel I. Miller,Natalie C. J. Strynadka +14 more
TL;DR: Using an integrated structural and experimental approach, ring models for the periplasmic domain of EscC are generated and placed in the context of the assembled T3SS, providing evidence for direct interaction between the outer membrane and inner membrane ring components and an unprecedented span of the outer membranes secretin.
Journal ArticleDOI
Antimicrobial Peptides Activate the Rcs Regulon through the Outer Membrane Lipoprotein RcsF
TL;DR: RcsFCDB activation in response to CAMP-induced membrane disorder is a result of a change in structure or availability of RcsF to the IM signaling constituents of the Rcs phosphorelay, which contributes to survival from polymyxin B exposure.
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Salmonella sensing of anti‐microbial mechanisms to promote survival within macrophages
TL;DR: Mechanisms by which Salmonella interacts with macrophages are discussed and the role of antimicrobial peptides and pH in PhoQ activation is focused on.
Journal ArticleDOI
Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics.
Kapil Gadkar,Cinthia V. Pastuskovas,Jennifer Le Couter,J. Michael Elliott,Jianhuan Zhang,Chingwei V. Lee,Sarah Sanowar,Germaine Fuh,Hok Seon Kim,T. Noelle Lombana,Christoph Spiess,Makia Nakamura,Phil Hass,Whitney Shatz,Y. Gloria Meng,Justin Scheer +15 more
TL;DR: It is demonstrated that protein molecular weight and Fc region do not play a critical role in ocular PK, as they do systemically, and the mathematical model supports the selection of the "ideal therapeutic" by predicting ocular and systemic PK of any antibody format for any dose regimen.