Sasha Lazetic

TL;DR: The identification of ligands for HLA-E is reported, which shows that a subset of HLA class I alleles has been shown to inhibit killing by CD94/NKG2A+ NK-cell clones, and only the HLA alleles that possess a leader peptide capable of upregulating Hla-E surface expression confer resistance toNK-cell-mediated lysis.

TL;DR: Residual tumors are enriched in colon tumors following chemotherapy and remain capable of rapidly regenerating tumors from which they originated, thereby suggesting avenues for improving cancer therapy.

TL;DR: A therapeutic approach to targeting the Wnt pathway with a monoclonal antibody, OMP-18R5, which interacts with five Fzd receptors through a conserved epitope within the extracellular domain and blocks canonical Wnt signaling induced by multiple Wnt family members.

TL;DR: It is demonstrated that CD94 glycoproteins form disulfide-bonded heterodimers with the NKG2A/B, NKG 2C, andNKG2E gly Coproteins, providing for the creation of a diverse NK cell repertoire.

TL;DR: It is found that specifically inhibiting human DLL4 in the tumor, either alone or in combination with the chemotherapeutic agent irinotecan, reduced cancer stem cell frequency, as shown by flow cytometric and in vivo tumorigenicity studies.