Jeffrey P. Houchins

TL;DR: The preferential expansion of a unique subset of NK cells coexpressing the activating CD94–NKG2C receptor and CD57 in CMV+ donors is demonstrated and it is proposed that CD57 might provide a marker of “memory” NK cells that have been expanded in response to infection.

TL;DR: Peptide sequence homology searches demonstrate that the NKG2 peptides are members of a supergene family that includes several other type II membrane proteins that is characterized by the presence of a C-type animal lectin domain, and several of its members have demonstrated transmembrane signaling capability.

TL;DR: It is demonstrated that CD94 glycoproteins form disulfide-bonded heterodimers with the NKG2A/B, NKG 2C, andNKG2E gly Coproteins, providing for the creation of a diverse NK cell repertoire.

TL;DR: It is demonstrated that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1–NKG2D interaction.

TL;DR: Examination of cell extracts from NK cell clones demonstrates that individual NKG2 family members are expressed on subsets of NK cells, and inhibition and activation of transmembrane signals in NK cells are found to be inhibitory and activating.