S
Satoshi Takabuchi
Researcher at Kyoto University
Publications - 16
Citations - 898
Satoshi Takabuchi is an academic researcher from Kyoto University. The author has contributed to research in topics: Gene expression & Transcription factor. The author has an hindex of 13, co-authored 16 publications receiving 833 citations. Previous affiliations of Satoshi Takabuchi include Kansai Medical University.
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Journal ArticleDOI
Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
Kenji Kasuno,Kenji Kasuno,Satoshi Takabuchi,Kazuhiko Fukuda,Shinae Kizaka-Kondoh,Junji Yodoi,Junji Yodoi,Takehiko Adachi,Gregg L. Semenza,Kiichi Hirota +9 more
TL;DR: It is concluded that the NO donor NOC18 induces Hif-1α synthesis under conditions of NO formation during normoxia and that hydroxylation of HIF-1 α is not regulated by NOC 18.
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LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner.
Kenichiro Nishi,Tomoyuki Oda,Satoshi Takabuchi,Satoshi Takabuchi,Seiko Oda,Seiko Oda,Kazuhiko Fukuda,Takehiko Adachi,Gregg L. Semenza,Koh Shingu,Kiichi Hirota,Kiichi Hirota +11 more
TL;DR: LPS-induced ROS generation and HIF-1 activation required the expression of Toll-like receptor 4 or myeloid differentiation factor (MyD) 88, thus providing a molecular basis for the selective activation of Hif-1 in differentiated THP-1 cells.
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Activation of hypoxia-inducible factor 1 during macrophage differentiation
Tomoyuki Oda,Kiichi Hirota,Kenichiro Nishi,Satoshi Takabuchi,Seiko Oda,Hiroko Yamada,Toshiyuki Arai,Kazuhiko Fukuda,Toru Kita,Takehiko Adachi,Gregg L. Semenza,Ryuji Nohara +11 more
TL;DR: It is demonstrated that macrophage differentiation of THP-1 cells or monocytes from peripheral blood induces increased expression of both Hif-1alpha and HIF-1beta as well as increased HIF -1 transcriptional activity leading to increased expression on target genes, which is required for functional maturation.
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Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner
Seiko Oda,Tomoyuki Oda,Kenichiro Nishi,Satoshi Takabuchi,Takuhiko Wakamatsu,Tomoharu Tanaka,Takehiko Adachi,Kazuhiko Fukuda,Gregg L. Semenza,Kiichi Hirota +9 more
TL;DR: It is demonstrated that intracellular overexpression or extracellular administration of MIF enhances activation of HIF-1 under hypoxic conditions in MCF-7 cells, providing a molecular mechanism for promotion of tumorigenesis by MIF.
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Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner
Shinichi Kai,Tomoharu Tanaka,Hiroki Daijo,Hiroshi Harada,Shun Kishimoto,Kengo Suzuki,Satoshi Takabuchi,Keizo Takenaga,Kazuhiko Fukuda,Kiichi Hirota +9 more
TL;DR: It is shown that H(2)S modulates intracellular O( 2) homeostasis and regulates activation of HIF-1 and the subsequent gene expression induced by hypoxia by using an in vitro system with established cell lines and an in vivo system in mice.