H
Hiroshi Harada
Researcher at Kyoto University
Publications - 472
Citations - 8313
Hiroshi Harada is an academic researcher from Kyoto University. The author has contributed to research in topics: Cognitive radio & Orthogonal frequency-division multiplexing. The author has an hindex of 41, co-authored 442 publications receiving 7173 citations. Previous affiliations of Hiroshi Harada include University of Tokyo & National Institute of Information and Communications Technology.
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Correction: Corrigendum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels
Hiroshi Harada,Masahiro Inoue,Satoshi Itasaka,Kiichi Hirota,Akiyo Morinibu,Kazumi Shinomiya,Lihua Zeng,Guangfei Ou,Yuxi Zhu,Michio Yoshimura,W. Gillies McKenna,Ruth J. Muschel,Masahiro Hiraoka +12 more
TL;DR: Images corresponding to a time point of 16 h were inadvertently used to represent immunohistochemical labelling 3 days after tamoxifen injection and are included in the revised figure below.
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Tumor hypoxia : A target for selective cancer therapy
TL;DR: Progress is described on the biological aspects of tumor hypoxia and a compilation of the recent molecular approaches used to target hypoxic tumors is provided, including a work with a unique Hypoxia‐targeting protein drug, TOP3, with which to address the above three difficulties.
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HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
TL;DR: Findings revealing that a novel HIF-1-activating factor enhances the antioxidant capacity and resultant radioresistance of cancer cells though reprogramming of the glucose metabolic pathway are summarized.
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Synthesis and biological evaluation of indolyl chalcones as antitumor agents
TL;DR: Indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.
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UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α
Yoko Goto,Lihua Zeng,Chan Joo Yeom,Yuxi Zhu,Akiyo Morinibu,Kazumi Shinomiya,Minoru Kobayashi,Kiichi Hirota,Satoshi Itasaka,Michio Yoshimura,Keiji Tanimoto,Masae Torii,Terumasa Sowa,Toshi Menju,Makoto Sonobe,Hideaki Kakeya,Masakazu Toi,Hiroshi Date,Ester M. Hammond,Masahiro Hiraoka,Hiroshi Harada +20 more
TL;DR: It is shown that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of Hif-1α, the regulatory subunit of HIF-1, and consequently promotes metastasis.