Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
Kenji Kasuno,Kenji Kasuno,Satoshi Takabuchi,Kazuhiko Fukuda,Shinae Kizaka-Kondoh,Junji Yodoi,Junji Yodoi,Takehiko Adachi,Gregg L. Semenza,Kiichi Hirota +9 more
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TLDR
It is concluded that the NO donor NOC18 induces Hif-1α synthesis under conditions of NO formation during normoxia and that hydroxylation of HIF-1 α is not regulated by NOC 18.About:
This article is published in Journal of Biological Chemistry.The article was published on 2004-01-23 and is currently open access. It has received 204 citations till now. The article focuses on the topics: Phosphatidylinositol 3-kinase signaling & Phosphatidylinositol.read more
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Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
Journal ArticleDOI
Hypoxia-inducible factor-1 (HIF-1).
Qingdong Ke,Max Costa +1 more
TL;DR: Overexpression of HIF-1 has been found in various cancers, and targeting Hif-1 could represent a novel approach to cancer therapy.
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The role of nitric oxide in tumour progression
TL;DR: Current understanding of the role of NO in tumour progression, especially in relation to angiogenesis and vascular functions is summarized and potential strategies for cancer treatment that modulate NO production and/or its downstream signalling pathways are discussed.
Journal ArticleDOI
PI3K/AKT/mTOR Pathway in Angiogenesis
Jayashree Karar,Amit Maity +1 more
TL;DR: The PI3K pathway plays an important role in regulating angiogenesis both in normal tissues and in cancers, and numerous inhibitors targeting the PI3k/AKT/mTOR pathway have been developed, and these agents have been shown to decrease VEGF secretion and angiynthesis.
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Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
TL;DR: A constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit, both spatially and temporally, in the hypoxic environment of tumours.
References
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
TL;DR: Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer in hypoxic cells.
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Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Panu Jaakkola,David R. Mole,Ya-Min Tian,Michael I. Wilson,Janine Gielbert,Simon J. Gaskell,Alex von Kriegsheim,Holger F. Hebestreit,Mridul Mukherji,Christopher J. Schofield,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe +12 more
TL;DR: It is shown that the interaction between human pVHL and a specific domain of the HIF-1α subunit is regulated through hydroxylation of a proline residue by an enzyme the authors have termed Hif-α prolyl-hydroxylase (HIF-PH).
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
Mircea Ivan,Keiichi Kondo,Haifeng Yang,William Y. Kim,Jennifer Valiando,Michael Ohh,Adrian Salic,John M. Asara,William S. Lane,William G. Kaelin,William G. Kaelin +10 more
TL;DR: It is found that human pVHL binds to a short HIF-derived peptide when a conserved proline residue at the core of this peptide is hydroxylated, which may play a key role in mammalian oxygen sensing.
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1.
Jo A. Forsythe,Bing-Hua Jiang,Narayan V. Iyer,Faton Agani,Sandra W. Leung,Robert D. Koos,Gregg L. Semenza +6 more
TL;DR: HIF-1 is implicate in the activation of VEGF transcription in hypoxic cells and this work demonstrates the involvement of Hif-1 in theactivation of V EGF transcription.