S
Satu Helske
Researcher at Forest Research Institute
Publications - 21
Citations - 1318
Satu Helske is an academic researcher from Forest Research Institute. The author has contributed to research in topics: Aortic valve stenosis & Aortic valve. The author has an hindex of 15, co-authored 19 publications receiving 1246 citations. Previous affiliations of Satu Helske include Helsinki University Central Hospital.
Papers
More filters
Journal ArticleDOI
Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies
TL;DR: The results suggest that low maternal serum PlGF and increased placental expression of its receptor VEGFR-1 are associated with pre-eclampsia and FGR.
Journal ArticleDOI
Induction of local angiotensin II-producing systems in stenotic aortic valves
Satu Helske,Ken A. Lindstedt,Mika Laine,Mikko I. Mäyränpää,Kalervo Werkkala,Jyri Lommi,Heikki Turto,Markku Kupari,Petri T. Kovanen +8 more
TL;DR: Angiotensin-converting enzyme and chymase, two Ang II-forming enzymes, are locally expressed in aortic valves, and owing to infiltration of macrophages and MCs, are further upregulated in stenotic valves.
Journal ArticleDOI
Aortic valve stenosis: an active atheroinflammatory process.
TL;DR: Findings regarding the interaction of inflammatory cells, lipids, mediators of calcification, and renin–angiotensin system in stenotic valves support the current opinion of aortic valve stenosis being an actively regulated disease, potentially amenable to targeted molecular therapy.
Journal ArticleDOI
Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves.
Satu Helske,Suvi Syväranta,Markku Kupari,Jani Lappalainen,Mika Laine,Jyri Lommi,Heikki Turto,Mikko I. Mäyränpää,Kalervo Werkkala,Petri T. Kovanen,Ken A. Lindstedt +10 more
TL;DR: In stenotic aortic valves, mast cell-derived cathepsin G may cause adverse valve remodelling and AS progression.
Journal ArticleDOI
Increased Expression of Elastolytic Cathepsins S, K, and V and Their Inhibitor Cystatin C in Stenotic Aortic Valves
Satu Helske,Suvi Syväranta,Ken A. Lindstedt,Jani Lappalainen,Katariina Öörni,Mikko I. Mäyränpää,Jyri Lommi,Heikki Turto,Kalervo Werkkala,Markku Kupari,Petri T. Kovanen +10 more
TL;DR: Stenotic aortic valves show increased expression and activity of elastolytic cathepsins S, K, and V, which may accelerate the destruction of aortsic valvular extracellular matrix, so promoting the progression of aortIC stenosis.