M
Mikko I. Mäyränpää
Researcher at University of Helsinki
Publications - 91
Citations - 3082
Mikko I. Mäyränpää is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 29, co-authored 74 publications receiving 2553 citations. Previous affiliations of Mikko I. Mäyränpää include Helsinki University Central Hospital & Forest Research Institute.
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Journal ArticleDOI
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
Gabor Foldes,Ferenc Horkay,István Szokodi,István Szokodi,Olli Vuolteenaho,Mika Ilves,Ken A. Lindstedt,Mikko I. Mäyränpää,Balazs Sarman,Leila Seres,Réka Skoumal,Zoltán Lakó-Futó,Rudolf deChâtel,Rudolf deChâtel,Heikki Ruskoaho,Miklós Tóth,Miklós Tóth +16 more
TL;DR: The results suggest that a new cardiac regulatory peptide, apelin, and APJ receptor may contribute to the pathophysiology of human CHF.
Journal ArticleDOI
Induction of local angiotensin II-producing systems in stenotic aortic valves
Satu Helske,Ken A. Lindstedt,Mika Laine,Mikko I. Mäyränpää,Kalervo Werkkala,Jyri Lommi,Heikki Turto,Markku Kupari,Petri T. Kovanen +8 more
TL;DR: Angiotensin-converting enzyme and chymase, two Ang II-forming enzymes, are locally expressed in aortic valves, and owing to infiltration of macrophages and MCs, are further upregulated in stenotic valves.
Journal ArticleDOI
Neuropathologic features of four autopsied COVID-19 patients.
Jonas Kantonen,Shamita Mahzabin,Mikko I. Mäyränpää,Olli Tynninen,Anders Paetau,Noora Andersson,Antti Sajantila,Olli Vapalahti,Olli Carpén,Eliisa Kekäläinen,Anu Kantele,Liisa Myllykangas +11 more
TL;DR: A small autopsy series demonstrates various hypoxia‐associated neuropathological features in COVID‐19 patients, but no evidence of neurotropism or meningitis/encephalitis.
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VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
Riikka Kivelä,Maija Bry,Marius R. Robciuc,Markus Räsänen,Miia Taavitsainen,Johanna M.U. Silvola,Antti Saraste,Juha J. Hulmi,Andrey Anisimov,Mikko I. Mäyränpää,Mikko I. Mäyränpää,Jan H.N. Lindeman,Lauri Eklund,Sanna Hellberg,Ruslan Hlushchuk,Zhen W. Zhuang,Michael Simons,Valentin Djonov,Juhani Knuuti,Eero Mervaala,Kari Alitalo +20 more
TL;DR: The data indicate that VEGF‐B could be used to increase the coronary vasculature and to reprogram myocardial metabolism to improve cardiac function in ischemic heart disease.
Journal ArticleDOI
OSBP-related Protein 8 (ORP8) Suppresses ABCA1 Expression and Cholesterol Efflux from Macrophages
Daoguang Yan,Mikko I. Mäyränpää,Jenny Wong,Julia Perttilä,Markku Lehto,Matti Jauhiainen,Petri T. Kovanen,Christian Ehnholm,Andrew J. Brown,Vesa M. Olkkonen +9 more
TL;DR: The data identify ORP8 as a negative regulator of ABCA1 expression and macrophage cholesterol efflux and may, thus, modulate the development of atherosclerosis.