S
Saurabh K. Gupta
Researcher at Eastern Virginia Medical School
Publications - 13
Citations - 339
Saurabh K. Gupta is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 7 publications receiving 313 citations.
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Journal Article
Serum Levels of an Isoform of Apolipoprotein A-II as a Potential Marker for Prostate Cancer
Gunjan Malik,Michael D. Ward,Saurabh K. Gupta,Michael W. Trosset,William E. Grizzle,Bao Ling Adam,Jose I. Diaz,O. John Semmes +7 more
TL;DR: The ability of ApoA-II to detect disease in patients with normal prostate-specific antigen suggests potential utility of the marker in identifying indolent disease.
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HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.
Sarah S. Durkin,Xin Guo,Kimberly A. Fryrear,Valia T. Mihaylova,Saurabh K. Gupta,S. Mehdi Belgnaoui,Abdelali Haoudi,Gary M. Kupfer,O. John Semmes +8 more
TL;DR: It is demonstrated that DNA-dependent protein kinase (DNA-PK) is a member of the Tax·Chk2 nuclear complex and proposed that Tax binds to and stabilizes a protein complex with DNA- PK and Chk2, resulting in a saturation of DNA-PK-mediated damage repair response.
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Human T-cell Leukemia Virus Type 1 Tax Oncoprotein Prevents DNA Damage-induced Chromatin Egress of Hyperphosphorylated Chk2
TL;DR: It is proposed that Tax binding via the Chk1 kinase domain sequesters phosphorylated Chk2 within chromatin, thus hindering chromatin egress and appropriate response to DNA damage.
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Dimerization and a Novel Tax Speckled Structure Localization Signal Are Required for Tax Nuclear Localization
TL;DR: This study identified a novel region in Tax that targets the protein to discrete nuclear foci that is both necessary and sufficient for directing proteins to TSS, and defined additional domains in Tax specific for nuclear localization and subnuclear targeting.
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The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription
TL;DR: It is proposed that recruitment of ATFx to the HTLV-1 LTR serves to link viral transcription with critical events in cellular homeostasis.