S
Savitha Subramanian
Researcher at University of Washington
Publications - 46
Citations - 2253
Savitha Subramanian is an academic researcher from University of Washington. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 22, co-authored 43 publications receiving 1844 citations.
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Journal ArticleDOI
Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
Christopher E. Savard,Christopher E. Savard,Erica V. Tartaglione,Rahul Kuver,W. Geoffrey Haigh,Geoffrey C. Farrell,Savitha Subramanian,Alan Chait,Matthew M. Yeh,LeBris S. Quinn,George N. Ioannou,George N. Ioannou +11 more
TL;DR: Dietary fat and dietary cholesterol interact synergistically to induce the metabolic and hepatic features of NASH, whereas neither factor alone is sufficient to cause NASH in mice.
Journal ArticleDOI
Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice
Savitha Subramanian,Leela Goodspeed,Shari A. Wang,Jinkyu Kim,Lixia Zeng,George N. Ioannou,W. Geoffrey Haigh,Matthew M. Yeh,Kris V. Kowdley,Kevin D. O'Brien,Subramaniam Pennathur,Alan Chait +11 more
TL;DR: Dietary cholesterol appears to confer a second “hit” that results in a distinct hepatic phenotype characterized by increased inflammation and oxidative stress, and LDLR−/− mice fed diabetogenic diets may be useful models for studying human NASH.
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Dietary Cholesterol Worsens Adipose Tissue Macrophage Accumulation and Atherosclerosis in Obese LDL Receptor–Deficient Mice
Savitha Subramanian,Chang Yeop Han,Tsuyoshi Chiba,Timothy S. McMillen,Shari A. Wang,Antonio Haw,Elizabeth A. Kirk,Kevin D. O'Brien,Alan Chait +8 more
TL;DR: Obesity-induced macrophage accumulation in adipose tissue is exacerbated by dietary cholesterol, which is associated with insulin resistance, systemic inflammation, and increased atherosclerosis in this mouse model.
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Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
Chang Yeop Han,Savitha Subramanian,Christina K. Chan,Mohamed Omer,Tsuyoshi Chiba,Thomas N. Wight,Alan Chait +6 more
TL;DR: It is hypothesized that adipocyte hypertrophy leads to increased production of SAA and hyaluronan, which act in concert to recruit and retain monocytes, thereby leading to local inflammation in adipose tissue.
Journal ArticleDOI
Hypertriglyceridemia secondary to obesity and diabetes.
Savitha Subramanian,Alan Chait +1 more
TL;DR: Moderate hypertriglyceridemia increases cardiovascular risk, while marked hypertrIGlyceridemic states should be considered a risk for pancreatitis.