T
Thomas N. Wight
Researcher at Benaroya Research Institute
Publications - 388
Citations - 26771
Thomas N. Wight is an academic researcher from Benaroya Research Institute. The author has contributed to research in topics: Versican & Extracellular matrix. The author has an hindex of 88, co-authored 326 publications receiving 24945 citations. Previous affiliations of Thomas N. Wight include Okayama University & University of Washington.
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Journal ArticleDOI
Human tissue-engineered blood vessels for adult arterial revascularization
Nicolas L'Heureux,Nathalie Dusserre,Gerhardt Konig,Braden Victor,Paul A. Keire,Thomas N. Wight,Nicolas Chronos,Andrew E. Kyles,Clare R. Gregory,Grant Hoyt,Robert C. Robbins,Todd N. McAllister +11 more
TL;DR: These results indicate that a completely biological and clinically relevant TEBV can be assembled exclusively from an individual's own cells, without relying upon synthetic or exogenous scaffolding.
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The extracellular matrix: an active or passive player in fibrosis?
TL;DR: Targeting components of the ECM as cells respond to injury and inflammatory stimuli holds promise as a means to avoid development of fibrosis and direct the wound-healing process toward reestablishment of a healthy equilibrium.
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Versican: a versatile extracellular matrix proteoglycan in cell biology
TL;DR: The highly interactive nature of versican provides a basis for its importance as a structural molecule, creating loose and hydrated matrices during key events in development and disease.
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Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy
TL;DR: The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and noncollagenous glycoproteins, and this activity may in part be beneficial to the drugs' disease-modifying properties.
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Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells
TL;DR: Data suggest that organization of HA- and versican-rich pericellular matrices may facilitate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.