S
Schlegel Kelly-Ann
Researcher at Merck & Co.
Publications - 4
Citations - 174
Schlegel Kelly-Ann is an academic researcher from Merck & Co.. The author has contributed to research in topics: Allosteric regulation & Calcium channel. The author has an hindex of 3, co-authored 4 publications receiving 165 citations.
Papers
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Journal ArticleDOI
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
William D. Shipe,James C. Barrow,Zhi Qiang Yang,Craig W. Lindsley,Craig W. Lindsley,F. Vivien Yang,Schlegel Kelly-Ann,Youheng Shu,Kenneth E. Rittle,Mark G. Bock,Mark G. Bock,George D. Hartman,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Emily D. Adarayan,Thomayant Prueksaritanont,Matthew M. Zrada,Victor N. Uebele,Cindy E. Nuss,Thomas M. Connolly,Scott M. Doran,Steven V. Fox,Richard L. Kraus,Michael J. Marino,Michael J. Marino,Valerie Kuzmick Graufelds,Hugo M. Vargas,Hugo M. Vargas,Patricia B. Bunting,Martha Hasbun-Manning,Rose M. Evans,Kenneth S. Koblan,John J. Renger +33 more
TL;DR: Structural modification of the p Piperidine leads 1 and 2 afforded the fluorinated piperidine ( S)- 5, a potent and selective antagonist that displayed in vivo CNS efficacy without adverse cardiovascular effects.
Journal ArticleDOI
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists.
Schlegel Kelly-Ann,Zhi Qiang Yang,Thomas S. Reger,Youheng Shu,Rowena V. Cube,Kenneth E. Rittle,Phung Bondiskey,Mark G. Bock,George D. Hartman,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Thomayant Prueksaritanont,Cindy E. Nuss,Scott M. Doran,Steven V. Fox,Susan L. Garson,Richard L. Kraus,Yuxing Li,Victor N. Uebele,John J. Renger,James C. Barrow +21 more
TL;DR: 45 was identified as a potent T-type Ca(2+) channel antagonist with minimized PXR activation in a rat model of absence epilepsy and showed significant alterations of sleep architecture after oral dosing to rats as measured by EEG.
Patent
Quinoline amide m1 receptor positive allosteric modulators
TL;DR: In this paper, a quinoline amide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M 1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.
Patent
Quinoline amide compounds which are muscarinic m1 receptor positive allosteric modulators
TL;DR: In this paper, the M1 receptor positive allosteric modulators can be useful in the treatment of diseases in which the M 1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders.