V
Victor N. Uebele
Researcher at Merck & Co.
Publications - 58
Citations - 3346
Victor N. Uebele is an academic researcher from Merck & Co.. The author has contributed to research in topics: T-type calcium channel & Voltage-dependent calcium channel. The author has an hindex of 31, co-authored 57 publications receiving 3059 citations. Previous affiliations of Victor N. Uebele include Vanderbilt University & United States Military Academy.
Papers
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Journal ArticleDOI
Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel.
Victor N. Uebele,Armando Lagrutta,Theresa Wade,David J. Figueroa,Yuan Liu,Edward McKenna,Christopher P. Austin,Paul B. Bennett,Richard Swanson +8 more
TL;DR: The tissue-specific expression of these β-subunits may allow for the assembly of a large number of distinct BK channels in vivo, contributing to the functional diversity of native BK currents.
Journal ArticleDOI
Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow
Fanny M Dreyfus,Anne Tscherter,Adam C. Errington,John J. Renger,Hee-Sup Shin,Victor N. Uebele,Vincenzo Crunelli,Régis C. Lambert,Nathalie Leresche +8 more
TL;DR: Using TTA-P2, the first direct demonstration of the presence of a window component of Ca2+ channels in neurons and its contribution to the resting membrane potential of thalamic neurons and to the Up state of their intrinsically generated slow (<1 Hz) oscillation is provided.
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Essential Thalamic Contribution to Slow Waves of Natural Sleep
François David,Joscha T. Schmiedt,Joscha T. Schmiedt,Hannah L. Taylor,Gergely Orban,Giuseppe Di Giovanni,Victor N. Uebele,John J. Renger,Régis C. Lambert,Régis C. Lambert,N. Leresche,N. Leresche,Vincenzo Crunelli +12 more
TL;DR: It is demonstrated that the thalamus finely tunes the frequency of slow waves during non-REM sleep and anesthesia, and thus provides the first conclusive evidence that a dynamic interplay of the neocortical and thalamic oscillators ofSlow waves is required for the full expression of this key physiological EEG rhythm.
Journal ArticleDOI
Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses.
Zhuo Huang,Rafael Luján,Ivan Kadurin,Victor N. Uebele,John J. Renger,Annette C. Dolphin,Mala M. Shah +6 more
TL;DR: It is found that HCN1 subunits are also localized to the active zone of mature asymmetric synaptic terminals targeting mouse entorhinal cortical layer III pyramidal neurons, which represents a previously unknown mechanism by which HCN channels regulate synaptic strength and thereby neural information processing and network excitability.
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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.
TL;DR: It is found that selective pharmacological antagonism of T-channels inhibited spontaneous synaptic release of glutamate in superficial laminae I-II of the DH, while GABA release was spared, and these studies provide previously unknown information regarding the role of presynaptic T- channels in nociceptive signaling in the spinal cord.