M
Michael J. Marino
Researcher at Cephalon
Publications - 47
Citations - 3375
Michael J. Marino is an academic researcher from Cephalon. The author has contributed to research in topics: Metabotropic glutamate receptor & Metabotropic glutamate receptor 1. The author has an hindex of 28, co-authored 47 publications receiving 3223 citations. Previous affiliations of Michael J. Marino include Emory University & Merck & Co..
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Journal ArticleDOI
Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
Guido Mannaioni,Michael J. Marino,Ornella Valenti,Ornella Valenti,Stephen F. Traynelis,P. J. Conn +5 more
TL;DR: The use of two novel subtype-selective antagonists in experiments with whole-cell patch-clamp recording and Ca2+-imaging techniques revealed that each group I mGluR subtype plays distinct roles in regulating the function of CA1 pyramidal neurons.
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Metabotropic glutamate receptors in the basal ganglia motor circuit
TL;DR: New understanding of the rich distribution and diverse physiological roles of metabotropic glutamate receptors in the basal ganglia indicate that these receptors might have a key role in motor control and raise the exciting possibility that they might provide therapeutic targets for the treatment of Parkinson's disease and related disorders.
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Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-d-aspartate (NMDA) receptor currents in hippocampal pyramidal cells
TL;DR: This work demonstrates that the m1-muscarinic receptor gene product modulates excitatory synaptic transmission, and it has important implications in the study of learning and memory as well as the design of drugs to treat neurodegenerative diseases such as Alzheimer's.
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Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
Sudar Alagarsamy,Michael J. Marino,Susan T. Rouse,Robert W. Gereau,Stephen F. Heinemann,P. J. Conn +5 more
TL;DR: Evidence is found that this response is mediated by activation of a protein phosphatase and a resultant dephosphorylation of protein kinase C phosphorylation sites on mGluR5, which may be important in a number of normal and pathological processes that involve activation of the NMDA receptor.
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Distribution and roles of metabotropic glutamate receptors in the basal ganglia motor circuit: implications for treatment of Parkinson's disease and related disorders.
Susan T. Rouse,Michael J. Marino,Stefania Risso Bradley,Hazar Awad,Marion Wittmann,P. Jeffrey Conn +5 more
TL;DR: A review of the most recent advances in the understanding of mGluR localization and function in the basal ganglia motor circuit and the implications of those findings for the potential therapeutic role of metabotropic glutamate receptor-targeted compounds for Parkinson's disease is presented in this article.