P
Patricia B. Bunting
Researcher at Merck & Co.
Publications - 9
Citations - 658
Patricia B. Bunting is an academic researcher from Merck & Co.. The author has contributed to research in topics: Calcium channel & Acetylcholine. The author has an hindex of 8, co-authored 9 publications receiving 638 citations.
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Journal ArticleDOI
Decreased endothelium-dependent relaxation in New Zealand genetic hypertensive rats.
TL;DR: The results demonstrate that there exists a generalized defect in the relaxant ability of vascular smooth muscle from GH rats and suggest that this defect is coupled with a decreased responsiveness to endothelium-dependent vasodilators in this particular animal model of hypertension.
Journal ArticleDOI
Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
William D. Shipe,James C. Barrow,Zhi Qiang Yang,Craig W. Lindsley,Craig W. Lindsley,F. Vivien Yang,Schlegel Kelly-Ann,Youheng Shu,Kenneth E. Rittle,Mark G. Bock,Mark G. Bock,George D. Hartman,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Emily D. Adarayan,Thomayant Prueksaritanont,Matthew M. Zrada,Victor N. Uebele,Cindy E. Nuss,Thomas M. Connolly,Scott M. Doran,Steven V. Fox,Richard L. Kraus,Michael J. Marino,Michael J. Marino,Valerie Kuzmick Graufelds,Hugo M. Vargas,Hugo M. Vargas,Patricia B. Bunting,Martha Hasbun-Manning,Rose M. Evans,Kenneth S. Koblan,John J. Renger +33 more
TL;DR: Structural modification of the p Piperidine leads 1 and 2 afforded the fluorinated piperidine ( S)- 5, a potent and selective antagonist that displayed in vivo CNS efficacy without adverse cardiovascular effects.
Journal ArticleDOI
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Zhi-Qiang Yang,James C. Barrow,William D. Shipe,Kelly-Ann S. Schlegel,Youheng Shu,F. Vivien Yang,Craig W. Lindsley,Craig W. Lindsley,Kenneth E. Rittle,Mark G. Bock,Mark G. Bock,George D. Hartman,Victor N. Uebele,Cindy E. Nuss,Steven V. Fox,Richard L. Kraus,Scott M. Doran,Thomas M. Connolly,Cuyue Tang,Jeanine E. Ballard,Yuhsin Kuo,Emily D. Adarayan,Thomayant Prueksaritanont,Matthew M. Zrada,Michael J. Marino,Michael J. Marino,Valerie Kuzmick Graufelds,Anthony G. DiLella,Ian J. Reynolds,Hugo M. Vargas,Hugo M. Vargas,Patricia B. Bunting,Richard Woltmann,Michael M. Magee,Kenneth S. Koblan,John J. Renger +35 more
TL;DR: Compound 30 demonstrated a robust reduction in the number and duration of seizures at 33 nM plasma concentration, with no cardiovascular effects at up to 5.6 microM, and is a useful tool for probing the effects of T-type calcium channel inhibition.
Journal ArticleDOI
Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker
Catherine Abbadie,Owen B. McManus,Shu-Yu Sun,Randal M. Bugianesi,Ge Dai,Rodolfo Haedo,James B Herrington,Gregory J. Kaczorowski,McHardy M. Smith,Andrew M. Swensen,Vivien A. Warren,Brande S. Williams,Stephen P. Arneric,Cyrus Eduljee,Terrance P. Snutch,Elizabeth Tringham,Nina Jochnowitz,Annie Liang,D. Euan MacIntyre,Erin McGowan,Shruti Mistry,Valerie V. White,Scott B. Hoyt,Clare London,Kathryn A. Lyons,Patricia B. Bunting,Sylvia Volksdorf,Joseph L. Duffy +27 more
TL;DR: TROX-1 demonstrates that an orally available state-dependent Cav2 channel blocker may achieve a therapeutic window suitable for the treatment of chronic pain.
Journal Article
Blockade of endothelium-dependent relaxation by the amiloride analog dichlorobenzamil: possible role of Na+/Ca++ exchange in the release of endothelium-derived relaxant factor.
TL;DR: Although the presence of extracellular calcium is critically required for the expression of endothelium-dependent relaxation, the associated calcium translocation is not blocked by the organic calcium entry blockers and the results with dichlorobenzamil suggest that sodium-calcium exchange may be an important mechanistic step in the release of endotHelium-derived relaxant factor.