Scott E. Klewer

TL;DR: The results demonstrate the importance of HA in mammalian embryogenesis and the pivotal role of Has2 during mammalian development and reveal a previously unrecognized pathway for cell migration and invasion that is HA-dependent and involves Ras activation.

TL;DR: Cardiac morphogenesis as it relates to heart valve formation is reviewed and selected growth factors, intracellular signaling mediators, and extracellular matrix components involved in the creation and remodeling of endocardial cushions into mature cardiac structures are highlighted.

TL;DR: It is shown that hyaluronan-deficient AVC explants from Has2−/− embryos, which normally lack mesenchyme formation, are rescued by heregulin treatment, which restores phosphorylation of ErbB2 and ErBB3.

TL;DR: Both TGF beta2 and TGFbeta3 appear necessary for the full morphogenetic program of EMT in the chick, but only TGFBeta2 is expressed and obligatory for mammalian endocardial cushion cell transformation.

TL;DR: Compared with values in control subjects, end-systolic left ventricular posterior wall dimension and percent of left vent cardiac posterior wall thickening in doxorubicin-treated patients were decreased at baseline study and these findings were more clearly delineated with dobutamine stimulation.