S
Steven W. Kubalak
Researcher at Medical University of South Carolina
Publications - 41
Citations - 3744
Steven W. Kubalak is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Heart development & Retinoid X receptor. The author has an hindex of 24, co-authored 39 publications receiving 3611 citations. Previous affiliations of Steven W. Kubalak include University of California, San Diego.
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Journal ArticleDOI
Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme
Todd D. Camenisch,Andrew P. Spicer,Andrew P. Spicer,Tammy Brehm-Gibson,Jennifer Biesterfeldt,Mary Lou Augustine,Anthony Calabro,Steven W. Kubalak,Scott E. Klewer,John A. McDonald +9 more
TL;DR: The results demonstrate the importance of HA in mammalian embryogenesis and the pivotal role of Has2 during mammalian development and reveal a previously unrecognized pathway for cell migration and invasion that is HA-dependent and involves Ras activation.
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Epicardial retinoid X receptor is required for myocardial growth and coronary artery formation
Esther Merki,Monica Zamora,Monica Zamora,Angel Raya,Yasuhiko Kawakami,Jianming Wang,Xiaoxue Zhang,John B.E. Burch,Steven W. Kubalak,Perla Kaliman,Juan Carlos Izpisua Belmonte,Kenneth R. Chien,Kenneth R. Chien,Pilar Ruiz-Lozano,Pilar Ruiz-Lozano +14 more
TL;DR: It is shown that RXR α signaling in the epicardium is required for proper cardiac morphogenesis and an additional phenotype of defective coronary arteriogenesis associated with RXRα deficiency is detected and a retinoid-dependent Wnt signaling pathway that cooperates in epicardial epithelial-to-mesenchymal transformation is identified.
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Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.
TL;DR: It is suggested that RXRalpha functions in a neighboring compartment of the developing heart to generate a signal that is required for ventricular cardiomyocyte development and chamber maturation.
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Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis.
TL;DR: The region-specific expression of the M LC-2a and MLC-2v genes in their respective chambers during early cardiogenesis provides genetic markers for chamber specification (atrial and ventricular) in both the in vitro and in vivo context.
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Developmental Changes in Ionic Channel Activity in the Embryonic Murine Heart
TL;DR: These results have important implications for the physiology and development of the murine cardiac conduction system and will also serve as a baseline for future studies designed to investigate developmental changes of ion channel expression in the myocardium of both wild-type and genetically modified mice.