Raymond B. Runyan

TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.

TL;DR: A model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling is supported.

TL;DR: Cardiac morphogenesis as it relates to heart valve formation is reviewed and selected growth factors, intracellular signaling mediators, and extracellular matrix components involved in the creation and remodeling of endocardial cushions into mature cardiac structures are highlighted.

TL;DR: Data are presented here that transforming growth factor beta (TGF beta 1 or TGF beta 2), in combination with an explant of ventricular myocardium, will produce an epithelial-mesenchymal transformation by cultured AV canal endothelial cells in vitro and provide evidence that a member of the TGF Beta family is present and plays a role in the process of epithel-meschymal cell transformation in the embryonic heart.

TL;DR: Both TGF beta2 and TGFbeta3 appear necessary for the full morphogenetic program of EMT in the chick, but only TGFBeta2 is expressed and obligatory for mammalian endocardial cushion cell transformation.