Scott M. Seki

TL;DR: The contribution of S1R to the restraint of the inflammatory response is revealed and this work identifies sigma-1 receptor (S1R) as an essential inhibitor of cytokine production in a preclinical model of septic shock.

TL;DR: The data suggest that the function of LRP1 in microglia is to keep these cells in an anti-inflammatory and neuroprotective status during inflammatory insult, including experimental autoimmune encephalomyelitis and potentially in Multiple sclerosis.

TL;DR: This study generated an oligodendroglia-specific knockout of LRP1, which presents with normal myelin development, but is associated with better outcomes in two animal models of demyelination (EAE and cuprizone), and places OPCs as major regulators of neuroinflammation in an L RP1-dependent fashion.

TL;DR: The focus of this review is to discuss the metabolically independent functions of glycolytic enzymes and how these could impact T cells, agents of the immune system that are commonly considered as orchestrators of auto-inflammatory processes.

TL;DR: This work demonstrates that OPCs are transcriptionally diverse and separate into three distinct populations in the homeostatic brain, which show distinct transcriptional signatures and enrichment of biological processes unique to individual OPC populations.