Suna Onengut-Gumuscu

TL;DR: The complex genetic architecture of the risk regions of and refine the risk signals for celiac disease are defined, providing the next step toward uncovering the causal mechanisms of the disease.

TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.

TL;DR: This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations and refined the peak of association to a single gene for 19 loci, identified secondary independent effects at 6 loci and identified association to low-frequency variants at 4 loci.

TL;DR: A computational strategy, SNP2HLA, to impute classical alleles and amino acid polymorphisms at class I and class II HLA loci and how imputation and association testing at amino acid resolution can facilitate fine-mapping of primary MHC association signals is described.

TL;DR: In this paper, a Bayesian approach was used to define credible sets for the T1D-associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells.