S
Sean D. Colloms
Researcher at University of Glasgow
Publications - 51
Citations - 2680
Sean D. Colloms is an academic researcher from University of Glasgow. The author has contributed to research in topics: Site-specific recombination & Recombinase. The author has an hindex of 27, co-authored 49 publications receiving 2544 citations. Previous affiliations of Sean D. Colloms include Lawrence Berkeley National Laboratory & University of Oxford.
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Journal Article
Escherichia coli XerC recombinase is required for chromosomal segregation at cell division.
TL;DR: It is demonstrated that XerC also has a role in the segregation of replicated chromosomes at cell division, suggesting that the role of XerC/dif in chromosomal metabolism is to convert any chromosomal multimers (arising through homologous recombination) to monomers.
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The mechanism of transposition of Tc3 in C. elegans
TL;DR: A model is derived for the mechanism of T c3 jumping that probably applies to the entire family of Tc1/mariner transposable elements and shows that the transposon is excised incompletely.
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xerB, an Escherichia coli gene required for plasmid ColE1 site-specific recombination, is identical to pepA, encoding aminopeptidase A, a protein with substantial similarity to bovine lens leucine aminopeptidase.
TL;DR: The heritable stability of ColE1 is dependent on a site‐specific recombination system which acts to resolve plasmid multimers into monomers, and genetic and biochemical evidence suggests that xerB is identical to the E.coli and S.typhimurium pepA genes that encode aminopeptidase A.
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New Applications for Phage Integrases
TL;DR: This work focuses on the new areas of metabolic pathway construction and optimization, biocomputing, heterologous expression and multiplexed assembly techniques, and the advantages and disadvantages of each type as they are applied in genome engineering and synthetic biology.
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Recombination at ColE1 cer requires the Escherichia coli xerC gene product, a member of the lambda integrase family of site-specific recombinases
TL;DR: Site-specific recombination at the plasmid ColE1 cer site requires the Escherichia coli chromosomal gene xerC, which has been localized to the 85-min region of the E. coli chromosome, between cya and uvrD.