S
Sean P. David
Researcher at University of Chicago
Publications - 121
Citations - 4821
Sean P. David is an academic researcher from University of Chicago. The author has contributed to research in topics: Smoking cessation & Nicotine replacement therapy. The author has an hindex of 36, co-authored 114 publications receiving 4316 citations. Previous affiliations of Sean P. David include University of Bristol & Stanford University.
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Journal ArticleDOI
Clinical Interpretation and Implications of Whole-Genome Sequencing
Frederick E. Dewey,Megan E. Grove,Cuiping Pan,Benjamin A. Goldstein,Jonathan A. Bernstein,Hassan Chaib,Jason D. Merker,Rachel L. Goldfeder,Gregory M. Enns,Sean P. David,Neda Pakdaman,Kelly E. Ormond,Colleen Caleshu,Kerry Kingham,Teri E. Klein,Michelle Whirl-Carrillo,Kenneth Sakamoto,Matthew T. Wheeler,Atul J. Butte,James M. Ford,Linda M. Boxer,John P. A. Ioannidis,Alan C. Yeung,Alan C. Yeung,Russ B. Altman,Themistocles L. Assimes,Themistocles L. Assimes,Michael Snyder,Michael Snyder,Euan A. Ashley,Thomas Quertermous +30 more
TL;DR: The use of WGS was associated with incomplete coverage of inherited disease genes, low reproducibility of detection of genetic variation with the highest potential clinical effects, and uncertainty about clinically reportable findings.
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Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention.
TL;DR: This review discusses the available empirical evidence for the presence of publication and reporting biases across the neuroimaging, animal, other preclinical, psychological, clinical trials, and genetics literature in the cognitive sciences.
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Ventral Striatum/Nucleus Accumbens Activation to Smoking-Related Pictorial Cues in Smokers and Nonsmokers: A Functional Magnetic Resonance Imaging Study
Sean P. David,Sean P. David,Marcus R. Munafò,Heidi Johansen-Berg,Stephen M. Smith,Robert D. Rogers,Paul M. Matthews,Robert Walton +7 more
TL;DR: This is the first demonstration of greater VS/NAc activation in addicted smokers than nonsmokers presented with smoking-related cues using fMRI, and a distributed reward signaling network consistent with cue reactivity studies of other drugs of abuse.
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A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.
Sean P. David,Naga Venkatesha Murthy,Eugenii A. Rabiner,Marcus R. Munafò,Elaine C. Johnstone,Robyn Jacob,Robert Walton,Paul M. Grasby +7 more
TL;DR: The results demonstrate for the first time that a functional polymorphism in the 5-HTT gene, but not the5-HT1A receptors gene, affects 5- HT1A receptor availability in man and may offer a plausible physiological mechanism underlying the association between 5-htTLPR genotype, behavioral traits, and mood states.
Journal ArticleDOI
Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
George R. Uhl,Qing-Rong Liu,Tomas Drgon,Catherine Johnson,Donna Walther,Jed E. Rose,Sean P. David,Raymond Niaura,Caryn Lerman +8 more
TL;DR: These results support polygenic genetics for success in abstaining from smoking, overlap with genetics of substance dependence and memory, and nominate gene variants for selective influences on therapeutic responses to bupropion vs NRT.