S
Sean T. O’Leary
Researcher at Anschutz Medical Campus
Publications - 304
Citations - 6100
Sean T. O’Leary is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Vaccination & Population. The author has an hindex of 33, co-authored 274 publications receiving 4383 citations. Previous affiliations of Sean T. O’Leary include University of Colorado Denver & Boston Children's Hospital.
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Transforming growth factor β—a mediator of immune deviation in seminal plasma
TL;DR: A better understanding of the significance and role of TGFβ in semen will facilitate development of novel therapies for immune-based infertility disorders and explain epidemiological observations linking acute and cumulative exposure to semen with successful placental development and pregnancy outcome.
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Seminal plasma regulates endometrial cytokine expression, leukocyte recruitment and embryo development in the pig
TL;DR: Findings implicate factors in seminal plasma in programming the trajectory of uterine cytokine expression and leukocyte trafficking during early pregnancy and in regulating pre-implantation embryo development in the pig.
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Effect of a Health Care Professional Communication Training Intervention on Adolescent Human Papillomavirus Vaccination: A Cluster Randomized Clinical Trial.
Amanda F. Dempsey,Jennifer Pyrznawoski,Steven Lockhart,Juliana Barnard,Elizabeth J. Campagna,Kathleen Garrett,Allison Fisher,L. Miriam Dickinson,L. Miriam Dickinson,Sean T. O’Leary +9 more
TL;DR: A health care professional communication intervention significantly improved HPV vaccine series initiation and completion among adolescent patients and had a greater effect in pediatric practices compared with family medicine practices and in private Practices compared with public ones.
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N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
Junhong Choi,Ka Weng Ieong,Hasan DeMirci,Jin Chen,Alexey Petrov,Arjun Prabhakar,Sean T. O’Leary,Dan Dominissini,Gideon Rechavi,Gideon Rechavi,S. Michael Soltis,Måns Ehrenberg,Joseph D. Puglisi +12 more
TL;DR: Bulk kinetic and single-molecule methods and measurements in an Escherichia coli translation system revealed that m6A modification of mRNA acts as a barrier to tRNA accommodation and translation elongation, demonstrating that chemical modification of RNA can change translational dynamics.
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Dynamic pathways of −1 translational frameshifting
TL;DR: This work applies single-molecule fluorescence to track the compositional and conformational dynamics of individual ribosomes at each codon during translation of a frameshift-inducing mRNA from the dnaX gene in Escherichia coli, highlighting multiple kinetic branchpoints during elongation.