S
Sebastian Horn
Researcher at University of Marburg
Publications - 5
Citations - 995
Sebastian Horn is an academic researcher from University of Marburg. The author has contributed to research in topics: microRNA & Neuroblastoma. The author has an hindex of 4, co-authored 5 publications receiving 919 citations. Previous affiliations of Sebastian Horn include Boston Children's Hospital.
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Journal ArticleDOI
Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
Tobias Otto,Sebastian Horn,Markus Brockmann,Ursula Eilers,Lars Schüttrumpf,Nikita Popov,Anna Marie Kenney,Johannes H. Schulte,Roderick L. Beijersbergen,Holger Christiansen,Bernd Berwanger,Martin Eilers +11 more
TL;DR: AURKA is identified as a gene that is required for the growth of MYCN-amplified neuroblastoma cells but largely dispensable for cells lacking amplified MYCN, and Aurora A has a critical function in regulating turnover of the N-Myc protein.
Journal ArticleDOI
MYCN regulates oncogenic MicroRNAs in neuroblastoma.
Johannes H. Schulte,Sebastian Horn,Tobias Otto,Birgit Samans,Lukas C. Heukamp,Ursula-Christa Eilers,Michael Krause,Kathy Astrahantseff,Ludger Klein-Hitpass,Reinhard Buettner,Alexander Schramm,Holger Christiansen,Martin Eilers,Angelika Eggert,Bernd Berwanger +14 more
TL;DR: It is shown here that miR‐221 is also induced by MYCN in neuroblastoma, and miRNA induction is reported to be a new mechanism of gene expression downregulation by Myc.
Journal Article
N-myc Regulates Oncogenic microRNAs in neuroblastoma
Johannes H. Schulte,Sebastian Horn,Birgit Samans,Lukas C. Heukamp,Ursula-Christa Eilers,Tobias Otto,Michael Krause,Kathy Astrahantseff,Reinhard Buettner,Alexander Schramm,Holger Christiansen,Martin Eilers,Angelika Eggert,Bernd Berwanger +13 more
TL;DR: In this article, the role of Nmyc in regulation of miRNA expression was analyzed and shown to be positively correlated with MYCN amplification in 28 primary neuroblastoma patients.
Journal ArticleDOI
MicroRNAs in the pathogenesis of neuroblastoma.
Johannes H. Schulte,Sebastian Horn,Sebastian Horn,Stefanie Schlierf,Alexander Schramm,Lukas C. Heukamp,Holger Christiansen,Reinhard Buettner,Bernd Berwanger,Angelika Eggert +9 more
TL;DR: The most recent attempts aiming to analyze the functional roles of microRNAs in neuroblastoma, the most devastating solid tumor in childhood, are reviewed.
SHORT REPORT MYCN regulates oncogenic MicroRNAs in neuroblastoma
Johannes Schulte,Sebastian Horn,Tobias Otto,Birgit Samans,Lukas C. Heukamp,Ursula-Christa Eilers,Michael Krause,Kathy Astrahantseff,Ludger Klein-Hitpass,Reinhard Buettner,Alexander Schramm,Holger Christiansen,Martin Eilers,Angelika Eggert,Bernd Berwanger +14 more
TL;DR: It is shown here that miR-221 is also induced by MYCN in neuroblastoma, and miRNA induction is reported to be a new mechanism of gene expression downregulation by Myc.