S
Sébastien Crépin
Researcher at University of Michigan
Publications - 14
Citations - 846
Sébastien Crépin is an academic researcher from University of Michigan. The author has contributed to research in topics: Regulon & Virulence. The author has an hindex of 11, co-authored 14 publications receiving 767 citations. Previous affiliations of Sébastien Crépin include Institut national de la recherche scientifique & Université de Montréal.
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Journal ArticleDOI
The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis.
TL;DR: The Pho regulon is clearly not a simple regulatory circuit for controlling phosphate homeostasis; it is part of a complex network important for both bacterial virulence and stress response.
Journal ArticleDOI
The Pho regulon and the pathogenesis of Escherichia coli.
Sébastien Crépin,Samuel M. Chekabab,Guillaume Le Bihan,Nicolas Bertrand,Charles M. Dozois,Charles M. Dozois,Josée Harel +6 more
TL;DR: It is illustrated that, in addition to regulating phosphate homeostasis, the Pho regulon plays a key role in regulating stress responses and virulence in Escherichia coli.
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Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection
Sargurunathan Subashchandrabose,Sara N. Smith,Valerie DeOrnellas,Sébastien Crépin,Monica M. Kole,Carina Zahdeh,Harry L. T. Mobley +6 more
TL;DR: Using transposon-directed insertion-site sequencing (TraDIS), novel A. baumannii fitness genes involved in the pathogenesis of mammalian infection are determined and it is demonstrated that FepA is involvement in the uptake of exogenous enterobactin in A. BaumannII.
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NsrR, GadE, and GadX interplay in repressing expression of the Escherichia coli O157:H7 LEE pathogenicity island in response to nitric oxide.
Priscilla Branchu,Stéphanie Matrat,Marjolaine Vareille,Annie Garrivier,Alexandra Durand,Sébastien Crépin,Josée Harel,Grégory Jubelin,Alain P. Gobert +8 more
TL;DR: It is demonstrated that NO inhibits the expression of genes belonging to LEE1, LEE4, and LEE5 operons, and that the NO sensor nitrite-sensitive repressor (NsrR) is a positive regulator of these operons by interacting directly with the RNA polymerase complex.
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Chromosomal Complementation Using Tn7 Transposon Vectors in Enterobacteriaceae.
TL;DR: This system provides a useful tool for single-copy complementation at an episomal site for research in bacterial genetics and microbial pathogenesis and could also be used for the introduction of foreign genes for use in biotechnology applications, vaccine development, or gene expression and gene fusion constructs.