S
Seiichi Harada
Publications - 5
Citations - 324
Seiichi Harada is an academic researcher. The author has contributed to research in topics: Brain morphometry & Cognition. The author has an hindex of 4, co-authored 5 publications receiving 304 citations.
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Journal ArticleDOI
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.
Takashi Ohnishi,Ryota Hashimoto,Takeyuki Mori,Kiyotaka Nemoto,Yoshiya Moriguchi,Hidehiro Iida,Hiroko Noguchi,Tetsuo Nakabayashi,Hiroaki Hori,Mayu Ohmori,Ryoutaro Tsukue,Kimitaka Anami,Naotugu Hirabayashi,Seiichi Harada,Kunimasa Arima,Osamu Saitoh,Hiroshi Kunugi +16 more
TL;DR: The findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia.
Journal ArticleDOI
Antipsychotic medication and cognitive function in schizophrenia.
Hiroaki Hori,Hiroko Noguchi,Ryota Hashimoto,Tetsuo Nakabayashi,Mayu Omori,Sho Takahashi,Ryotaro Tsukue,Kimitaka Anami,Naotsugu Hirabayashi,Seiichi Harada,Osamu Saitoh,Masao Iwase,Osami Kajimoto,Masatoshi Takeda,Shigeo Okabe,Hiroshi Kunugi +15 more
TL;DR: Evidence is provided for an association between antipsychotic medication and cognitive function and this association may be due to differential illness severity (e.g., non-standard treatment for severely ill patients who have severe cognitive impairment).
Journal ArticleDOI
A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls.
Ryota Hashimoto,Hiroko Noguchi,Hiroaki Hori,Tetsuo Nakabayashi,Tatsuyo Suzuki,Nakao Iwata,Norio Ozaki,Asako Kosuga,Masahiko Tatsumi,Kunitoshi Kamijima,Seiichi Harada,Masatoshi Takeda,Osamu Saitoh,Hiroshi Kunugi +13 more
TL;DR: Data suggest that DTNBP1 may have impact on parts of memory functions, and this haplotype did not affect IQ and its sub-scores as measured by the Wechsler Adult Intelligence Scale-Revised in both groups.
Journal ArticleDOI
Abnormal microstructures of the basal ganglia in schizophrenia revealed by diffusion tensor imaging.
Ryota Hashimoto,Takeyuki Mori,Kiyotaka Nemoto,Yoshiya Moriguchi,Hiroko Noguchi,Tetsuo Nakabayashi,Hiroaki Hori,Seiichi Harada,Hiroshi Kunugi,Osamu Saitoh,Takashi Ohnishi +10 more
TL;DR: Data from diffusion tensor imaging support the notion that myelination abnormalities in basal ganglia–thalamic system are related to the pathophysiology of schizophrenia.
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological
Takashi Ohnishi,Ryota Hashimoto,Takeyuki Mori,Kiyotaka Nemoto,Yoshiya Moriguchi,Hidehiro Iida,Hiroko Noguchi,Tetsuo Nakabayashi,Hiroaki Hori,Mayu Ohmori,Ryoutaro Tsukue,Kimitaka Anami,Naotugu Hirabayashi,Seiichi Harada,Kunimasa Arima,Osamu Saitoh,Hiroshi Kunugi +16 more
TL;DR: In this article, the authors examined whether the Val158Met polymorphism of the COMT gene has an impact on brain morphology in normal individuals and patients with schizophrenia and found that individuals homozygous for the Val-COMT allele demonstrated significant reduction of volumes in the left anterior cingulate cortex (ACC) and the right middle temporal gyrus (MTG) compared to Met-comT carriers.