H
Hiroaki Hori
Researcher at Tokyo Medical and Dental University
Publications - 149
Citations - 4648
Hiroaki Hori is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Major depressive disorder & Schizophrenia. The author has an hindex of 34, co-authored 138 publications receiving 3718 citations.
Papers
More filters
Journal ArticleDOI
Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression
TL;DR: An integrated schema of the pathological and recovery processes of depression is illustrated and several lines of evidence from postmortem studies, animal studies, blood levels, and genetic studies suggest that BDNF is involved in the pathogenesis of depression and in the mechanism of action of biological treatments for depression.
Journal ArticleDOI
Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
Daimei Sasayama,Kotaro Hattori,Chisato Wakabayashi,Toshiya Teraishi,Hiroaki Hori,Miho Ota,Sumiko Yoshida,Kunimasa Arima,Teruhiko Higuchi,Naoji Amano,Hiroshi Kunugi +10 more
TL;DR: The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded.
Journal ArticleDOI
Inflammation and post-traumatic stress disorder.
Hiroaki Hori,Yoshiharu Kim +1 more
TL;DR: Evidence suggestive of increased inflammation in PTSD is summarized and possible mechanisms of inflammation in this disorder are examined in terms of two different but interrelated perspectives: putative causes of increased proinflammatory activities and potential consequences that inflammation generates.
Journal ArticleDOI
The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia.
Takashi Ohnishi,Ryota Hashimoto,Takeyuki Mori,Kiyotaka Nemoto,Yoshiya Moriguchi,Hidehiro Iida,Hiroko Noguchi,Tetsuo Nakabayashi,Hiroaki Hori,Mayu Ohmori,Ryoutaro Tsukue,Kimitaka Anami,Naotugu Hirabayashi,Seiichi Harada,Kunimasa Arima,Osamu Saitoh,Hiroshi Kunugi +16 more
TL;DR: The findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia.
Journal ArticleDOI
Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease.
Miho Ota,Junko Matsuo,Ikki Ishida,Harumasa Takano,Yuma Yokoi,Hiroaki Hori,Sumiko Yoshida,Kinya Ashida,Kentaro Nakamura,Takeshi Takahashi,Hiroshi Kunugi +10 more
TL;DR: The chronic consumption of the ketogenic formula was suggested to have positive effects on verbal memory and processing speed in patients with AD and showed significant improvement in their immediate and delayed logical memory tests compared to their baseline scores.